Hydrophobic allergens from the bottom fraction membrane of hevea brasiliensis

Kesajee Mengumpun, Chatchai Tayapiwatana, Robert G. Hamilton, Pasuree Sangsupawanich, Rapepun Wititsuwannakul

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Several proteins of rubber latex have been recognized as allergens causing immediate hypersensitivity in humans. In this study, a bottom fraction membrane (BFM) protein preparation from Hevea brasiliensis trees grown in southern Thailand was used to detect specific IgE in four groups of serum samples. The first group included 170 samples of latex glove factory workers (LGWs); group 2 consisted of the sera of 35 health care workers (HCWs) who were repeatedly exposed to powdered latex gloves; groups 3 and 4 were 31 positive and 22 negative sera, respectively, obtained from Johns Hopkins University School of Medicine, Baltimore, USA, tested for IgE to latex allergen. It was found that 56/ 170 (33%), 5/35 (14%), 11/31 (35.5%) and 1/22 (4.5%) samples of the LGWs, HCWs, CAP+ and CAP- groups had significant IgE to the BFM proteins, respectively. However, of all subjects only one subject of group 1 had experienced allergic morbidity consisting of eczema, conjunctivitis and asthma. The IgE of this subject bound to a 55 kDa component in the rubber latex BFM preparation. Thus, this protein may be regarded as a novel, although minor, latex allergen. Further investigation is needed to characterize the component and to pinpoint its allergenic role.

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalAsian Pacific Journal of Allergy and Immunology
Issue number2-3
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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