Hydromorphone polymer implant: A potential alternative to methadone maintenance

Deborah J. Rhodes, Stuart A. Grossman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Although methadone maintenance remains the best available treatment for opioid addiction, the need for daily oral dosing limits the effectiveness of methadone as opioid substitution therapy. Limitations of methadone maintenance include the administrative costs and burdensome time commitment associated with daily clinic visits, the danger of illicit diversion and accidental overdose associated with oral dosing, the low rate of treatment retention, and inadequate treatment capacity. A new opioid delivery device awaiting approval for clinical use may overcome some of these limitations. The device, a button-size polymer containing hydromorphone, releases near constant levels of opioid when implanted subcutaneously. Because of its location and duration of effect, the polymer may eliminate the need for daily clinic visits, reduce the costs and time constraints of treatment, reduce the risk of illicit diversion, provide an incentive for compliance with initial methadone maintenance treatment, and increase treatment capacity and retention.

Original languageEnglish (US)
Pages (from-to)535-542
Number of pages8
JournalJournal of Substance Abuse Treatment
Issue number6
StatePublished - 1997
Externally publishedYes


  • Hydromorphone
  • Intravenous drug use
  • Methadone maintenance
  • Polymer

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Hydromorphone polymer implant: A potential alternative to methadone maintenance'. Together they form a unique fingerprint.

Cite this