Hydromorphone effects on human conversational speech

Maxine L. Stitzer, Mary E. McCaul, George E. Bigleow, Ira A. Liebson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The present study provides an objective assessment of the increased talkativeness associated with acute opiate drug administration. Speech of five methadone-maintenance subjects was recorded continuously for 1 h following the injection of 0, 10, 14, or 18 mg hydromorphone. Dose-related increases in subjects' speech were observed, while no systematic changes were seen in speech of an undrugged partner. Dose-related increases were also obtained on an adjective checklist measuring characteristic opiate signs and symptoms. The relationship between behavioral, subjective, and reinforcing drug effects is discussed.

Original languageEnglish (US)
Pages (from-to)402-404
Number of pages3
Issue number3
StatePublished - Sep 1 1984


  • Behavioral effects
  • Drug abusers
  • Drug reinforcement
  • Human speech
  • Hydromorphone
  • Opiate drugs
  • Subjective effects

ASJC Scopus subject areas

  • Pharmacology


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