Hydrogels to model 3D in vitro microenvironment of tumor vascularization

Hyun Ho Greco Song, Kyung Min Park, Sharon Gerecht

Research output: Contribution to journalReview articlepeer-review


A growing number of failing clinical trials for cancer therapy are substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is still very new. In this review, we explore current use of hydrogels and their design parameters to engineer vasculogenesis and angiogenesis and to evaluate the angiogenic capability of cancerous cells and tissues. By coupling these hydrogels with other technologies such as lithography and three-dimensional printing, one can create an advanced microvessel model as microfluidic channels to more accurately capture the native angiogenesis process.

Original languageEnglish (US)
Pages (from-to)19-29
Number of pages11
JournalAdvanced Drug Delivery Reviews
StatePublished - Dec 15 2014


  • Angiogenesis
  • ECM remodeling
  • Hydrogel
  • Three-dimensional cell culture
  • Tumor modeling

ASJC Scopus subject areas

  • Pharmaceutical Science


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