Abstract
The immune response to matrix (M) protein of measles virus was examined in patients with subacute sclerosing panencephalitis (SSPE) and controls. Antibodies specific for M and nucleocapsid (NC) proteins in 11 serum and 8 cerebrospinal fluid (CSF) samples from patients with SSPE were quantitated by enzyme-linked immunosorbent assay by using affinity-purified measles virus proteins. Geometric mean anti-NC antibody titers were higher in the serum (6.58 ± 0.98 [mean ± standard deviation]) and CSF (4.38 ± 0.74) of SSPE patients compared with controls. Anti-M antibodies were present in the serum and CSF of all SSPE samples tested but in titers lower than those of anti-NC antibodies. Geometric mean anti-M antibody titer was 3.35 ± 0.53 in sera from patients with SSPE compared with 3.05 ± 0.66 in sera from patients with other neurological diseases and 3.12 ± 0.74 in sera from healthy individuals. Geometric mean anti-M antibody titer was 2.59 ± 0.86 in the CSF of eight patients with SSPE compared with a mean
Original language | English (US) |
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Pages (from-to) | 2483-2489 |
Number of pages | 7 |
Journal | Journal of Virology |
Volume | 62 |
Issue number | 7 |
State | Published - 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology