Human polyomavirus-7–associated eruption successfully treated with acitretin

T. N. Canavan; J. W. Baddley; P. Pavlidakey; J. A. Tallaj; B. E. Elewski

doi:10.1111/ajt.14634

Human polyomavirus-7–associated eruption successfully treated with acitretin

T. N. Canavan, J. W. Baddley, P. Pavlidakey, J. A. Tallaj, B. E. Elewski

Research output: Contribution to journal › Article › peer-review

Abstract

Advances in molecular technologies have led to the discovery of several novel human polyomaviruses (HPyVs), including human polyomavirus-7 (HPyV-7). Although low levels of HPyV-7 are shed from apparently normal skin, recent reports have described clinically significant cutaneous infection in immunocompromised patients that manifests as generalized pruritic plaques. The pruritus can be severe, and treatment options have not been described. Herein we report HPyV-7 cutaneous infection in a heart transplant patient who experienced temporary improvement with intravenous cidofovir, and complete remission with acitretin. We report a case of HPyV-7 cutaneous infection demonstrating a good response to treatment.

Original language	English (US)
Pages (from-to)	1278-1284
Number of pages	7
Journal	American Journal of Transplantation
Volume	18
Issue number	5
DOIs	https://doi.org/10.1111/ajt.14634
State	Published - May 2018
Externally published	Yes

Keywords

biopsy
clinical research/practice
complication: infectious
dermatology
heart (allograft) function/dysfunction
immunosuppressant - mechanistic target of rapamycin (mTOR)
infection and infectious agents – viral: BK/JC/polyoma
infectious disease

ASJC Scopus subject areas

Immunology and Allergy
Transplantation
Pharmacology (medical)

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10.1111/ajt.14634

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title = "Human polyomavirus-7–associated eruption successfully treated with acitretin",

abstract = "Advances in molecular technologies have led to the discovery of several novel human polyomaviruses (HPyVs), including human polyomavirus-7 (HPyV-7). Although low levels of HPyV-7 are shed from apparently normal skin, recent reports have described clinically significant cutaneous infection in immunocompromised patients that manifests as generalized pruritic plaques. The pruritus can be severe, and treatment options have not been described. Herein we report HPyV-7 cutaneous infection in a heart transplant patient who experienced temporary improvement with intravenous cidofovir, and complete remission with acitretin. We report a case of HPyV-7 cutaneous infection demonstrating a good response to treatment.",

keywords = "biopsy, clinical research/practice, complication: infectious, dermatology, heart (allograft) function/dysfunction, immunosuppressant - mechanistic target of rapamycin (mTOR), infection and infectious agents – viral: BK/JC/polyoma, infectious disease",

author = "Canavan, {T. N.} and Baddley, {J. W.} and P. Pavlidakey and Tallaj, {J. A.} and Elewski, {B. E.}",

note = "Publisher Copyright: {\textcopyright} 2017 The American Society of Transplantation and the American Society of Transplant Surgeons",

year = "2018",

month = may,

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AU - Canavan, T. N.

AU - Baddley, J. W.

AU - Pavlidakey, P.

AU - Tallaj, J. A.

AU - Elewski, B. E.

PY - 2018/5

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KW - clinical research/practice

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KW - dermatology

KW - heart (allograft) function/dysfunction

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KW - infectious disease

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Human polyomavirus-7–associated eruption successfully treated with acitretin

Abstract

Keywords

ASJC Scopus subject areas

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