Human polyomavirus-7–associated eruption successfully treated with acitretin

T. N. Canavan, J. W. Baddley, P. Pavlidakey, J. A. Tallaj, B. E. Elewski

Research output: Contribution to journalArticlepeer-review

Abstract

Advances in molecular technologies have led to the discovery of several novel human polyomaviruses (HPyVs), including human polyomavirus-7 (HPyV-7). Although low levels of HPyV-7 are shed from apparently normal skin, recent reports have described clinically significant cutaneous infection in immunocompromised patients that manifests as generalized pruritic plaques. The pruritus can be severe, and treatment options have not been described. Herein we report HPyV-7 cutaneous infection in a heart transplant patient who experienced temporary improvement with intravenous cidofovir, and complete remission with acitretin. We report a case of HPyV-7 cutaneous infection demonstrating a good response to treatment.

Original languageEnglish (US)
Pages (from-to)1278-1284
Number of pages7
JournalAmerican Journal of Transplantation
Volume18
Issue number5
DOIs
StatePublished - May 2018
Externally publishedYes

Keywords

  • biopsy
  • clinical research/practice
  • complication: infectious
  • dermatology
  • heart (allograft) function/dysfunction
  • immunosuppressant - mechanistic target of rapamycin (mTOR)
  • infection and infectious agents – viral: BK/JC/polyoma
  • infectious disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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