Human papillomavirus, p53 and Cyclin D1 expression in oropharyngeal carcinoma

Rekha V. Kumar; S. S. Kadkol; R. Daniel; A. M. Shenoy; K. V. Shah

doi:10.1054/ijom.2002.0407

Human papillomavirus, p53 and Cyclin D1 expression in oropharyngeal carcinoma

Rekha V. Kumar, S. S. Kadkol, R. Daniel, A. M. Shenoy, K. V. Shah

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1 overexpression. There was no correlation between HPV status and either p53 or Cyclin D1 overexpression (P>0.05). These three variables also did not correlate with factors such as grade of the tumour, stage of the disease or lymph nodal metastasis at presentation.

Original language	English (US)
Pages (from-to)	539-543
Number of pages	5
Journal	International Journal of Oral and Maxillofacial Surgery
Volume	32
Issue number	5
DOIs	https://doi.org/10.1054/ijom.2002.0407
State	Published - Oct 2003
Externally published	Yes

Keywords

Cyclin
Oropharynx
Papillomaviruses
Protein p53
Tonsillar neoplasms

ASJC Scopus subject areas

Surgery
Oral Surgery
Otorhinolaryngology

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10.1054/ijom.2002.0407

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title = "Human papillomavirus, p53 and Cyclin D1 expression in oropharyngeal carcinoma",

abstract = "Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1 overexpression. There was no correlation between HPV status and either p53 or Cyclin D1 overexpression (P>0.05). These three variables also did not correlate with factors such as grade of the tumour, stage of the disease or lymph nodal metastasis at presentation.",

keywords = "Cyclin, Oropharynx, Papillomaviruses, Protein p53, Tonsillar neoplasms",

author = "Kumar, {Rekha V.} and Kadkol, {S. S.} and R. Daniel and Shenoy, {A. M.} and Shah, {K. V.}",

note = "Funding Information: Acknowledgments. We thank Manju Kaushal for assistance with immuno- histochemistry and C. Ramesh for statistical help. This study was supported in part by US Public Health Service Grant Number ROI DE13121 from the National Institutes of Health (KVS). RVK was supported by an International Cancer Technology Transfer Fellowship from the International Union Against Cancer.",

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AU - Kadkol, S. S.

AU - Daniel, R.

AU - Shenoy, A. M.

AU - Shah, K. V.

N1 - Funding Information: Acknowledgments. We thank Manju Kaushal for assistance with immuno- histochemistry and C. Ramesh for statistical help. This study was supported in part by US Public Health Service Grant Number ROI DE13121 from the National Institutes of Health (KVS). RVK was supported by an International Cancer Technology Transfer Fellowship from the International Union Against Cancer.

PY - 2003/10

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N2 - Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1 overexpression. There was no correlation between HPV status and either p53 or Cyclin D1 overexpression (P>0.05). These three variables also did not correlate with factors such as grade of the tumour, stage of the disease or lymph nodal metastasis at presentation.

AB - Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1 overexpression. There was no correlation between HPV status and either p53 or Cyclin D1 overexpression (P>0.05). These three variables also did not correlate with factors such as grade of the tumour, stage of the disease or lymph nodal metastasis at presentation.

KW - Cyclin

KW - Oropharynx

KW - Papillomaviruses

KW - Protein p53

KW - Tonsillar neoplasms

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Human papillomavirus, p53 and Cyclin D1 expression in oropharyngeal carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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