Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men: The HIM Study

Christine M.Pierce Campbell; Raphael P. Viscidi; B. Nelson Torres; Hui Yi Lin; William Fulp; Martha Abrahamsen; Eduardo Lazcano-Ponce; Luisa L. Villa; Aimee R. Kreimer; Anna R. Giuliano

doi:10.1093/infdis/jiw083

Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men: The HIM Study

Christine M.Pierce Campbell, Raphael P. Viscidi, B. Nelson Torres, Hui Yi Lin, William Fulp, Martha Abrahamsen, Eduardo Lazcano-Ponce, Luisa L. Villa, Aimee R. Kreimer, Anna R. Giuliano

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval,. 56-4.76).

Original language	English (US)
Pages (from-to)	45-48
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	214
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiw083
State	Published - Jul 1 2016

Keywords

HPV16
antibodies
men
oral HPV
serology

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiw083

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title = "Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men: The HIM Study",

abstract = "The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval,. 56-4.76).",

keywords = "HPV16, antibodies, men, oral HPV, serology",

author = "Campbell, {Christine M.Pierce} and Viscidi, {Raphael P.} and Torres, {B. Nelson} and Lin, {Hui Yi} and William Fulp and Martha Abrahamsen and Eduardo Lazcano-Ponce and Villa, {Luisa L.} and Kreimer, {Aimee R.} and Giuliano, {Anna R.}",

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AU - Viscidi, Raphael P.

AU - Torres, B. Nelson

AU - Lin, Hui Yi

AU - Fulp, William

AU - Abrahamsen, Martha

AU - Lazcano-Ponce, Eduardo

AU - Villa, Luisa L.

AU - Kreimer, Aimee R.

AU - Giuliano, Anna R.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval,. 56-4.76).

AB - The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval,. 56-4.76).

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KW - oral HPV

KW - serology

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Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men: The HIM Study

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