TY - JOUR
T1 - Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men
T2 - The HIM Study
AU - Campbell, Christine M.Pierce
AU - Viscidi, Raphael P.
AU - Torres, B. Nelson
AU - Lin, Hui Yi
AU - Fulp, William
AU - Abrahamsen, Martha
AU - Lazcano-Ponce, Eduardo
AU - Villa, Luisa L.
AU - Kreimer, Aimee R.
AU - Giuliano, Anna R.
N1 - Funding Information:
This work was supported by the NCI, NIH (grant R01 CA098803 to A. R. G.); the National Cancer Institute Intramural Program (to A. R. K.); the Investigator-Initiated Studies Program, Merck Sharp and Dohme (to A. R. G.); and the American Cancer Society (postdoctoral fellowship PF-13-222-01-MPC to C. M. P. C.).
Publisher Copyright:
© 2016 The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval,. 56-4.76).
AB - The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval,. 56-4.76).
KW - HPV16
KW - antibodies
KW - men
KW - oral HPV
KW - serology
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U2 - 10.1093/infdis/jiw083
DO - 10.1093/infdis/jiw083
M3 - Article
C2 - 26931445
AN - SCOPUS:84979222063
SN - 0022-1899
VL - 214
SP - 45
EP - 48
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -