TY - JOUR
T1 - Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1)
AU - Himmelbauer, Heinz
AU - Pohlschmidt, Marita
AU - Snarey, Angela
AU - Germino, Gregory G.
AU - Weinstat-Saslow, Debra
AU - Somlo, Stefan
AU - Reeders, Stephen T.
AU - Frischauf, Anna Maria
PY - 1992
Y1 - 1992
N2 - Autosomal dominant polycystic kidney disease (PKD1) is linked to the α-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed α-like globin gene. The markers we mapped are widely distributed over the region known to contain the PKD1 gene, and it is therefore likely that the mouse homologue of PKD1 is also located on mouse chromosome 17.
AB - Autosomal dominant polycystic kidney disease (PKD1) is linked to the α-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed α-like globin gene. The markers we mapped are widely distributed over the region known to contain the PKD1 gene, and it is therefore likely that the mouse homologue of PKD1 is also located on mouse chromosome 17.
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U2 - 10.1016/0888-7543(92)90198-2
DO - 10.1016/0888-7543(92)90198-2
M3 - Article
C2 - 1349580
AN - SCOPUS:0026509388
SN - 0888-7543
VL - 13
SP - 35
EP - 38
JO - Genomics
JF - Genomics
IS - 1
ER -