Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1)

Heinz Himmelbauer; Marita Pohlschmidt; Angela Snarey; Gregory G. Germino; Debra Weinstat-Saslow; Stefan Somlo; Stephen T. Reeders; Anna Maria Frischauf

doi:10.1016/0888-7543(92)90198-2

Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1)

Heinz Himmelbauer, Marita Pohlschmidt, Angela Snarey, Gregory G. Germino, Debra Weinstat-Saslow, Stefan Somlo, Stephen T. Reeders, Anna Maria Frischauf

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Autosomal dominant polycystic kidney disease (PKD1) is linked to the α-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed α-like globin gene. The markers we mapped are widely distributed over the region known to contain the PKD1 gene, and it is therefore likely that the mouse homologue of PKD1 is also located on mouse chromosome 17.

Original language	English (US)
Pages (from-to)	35-38
Number of pages	4
Journal	Genomics
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/0888-7543(92)90198-2
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1)",

abstract = "Autosomal dominant polycystic kidney disease (PKD1) is linked to the α-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed α-like globin gene. The markers we mapped are widely distributed over the region known to contain the PKD1 gene, and it is therefore likely that the mouse homologue of PKD1 is also located on mouse chromosome 17.",

author = "Heinz Himmelbauer and Marita Pohlschmidt and Angela Snarey and Germino, {Gregory G.} and Debra Weinstat-Saslow and Stefan Somlo and Reeders, {Stephen T.} and Frischauf, {Anna Maria}",

year = "1992",

doi = "10.1016/0888-7543(92)90198-2",

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T1 - Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1)

AU - Himmelbauer, Heinz

AU - Pohlschmidt, Marita

AU - Snarey, Angela

AU - Germino, Gregory G.

AU - Weinstat-Saslow, Debra

AU - Somlo, Stefan

AU - Reeders, Stephen T.

AU - Frischauf, Anna Maria

PY - 1992

Y1 - 1992

N2 - Autosomal dominant polycystic kidney disease (PKD1) is linked to the α-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed α-like globin gene. The markers we mapped are widely distributed over the region known to contain the PKD1 gene, and it is therefore likely that the mouse homologue of PKD1 is also located on mouse chromosome 17.

AB - Autosomal dominant polycystic kidney disease (PKD1) is linked to the α-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed α-like globin gene. The markers we mapped are widely distributed over the region known to contain the PKD1 gene, and it is therefore likely that the mouse homologue of PKD1 is also located on mouse chromosome 17.

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Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1)

Abstract

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