Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults

John V. Williams; James E. Crowe; Rachel Enriquez; Patricia Minton; R. Stokes Peebles; Robert G. Hamilton; Stanley Higgins; Marie Griffin; Tina V. Hartert

doi:10.1086/444392

Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults

John V. Williams, James E. Crowe, Rachel Enriquez, Patricia Minton, R. Stokes Peebles, Robert G. Hamilton, Stanley Higgins, Marie Griffin, Tina V. Hartert

School of Medicine

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up (odds ratio, 7 [95% confidence interval, 0.9-312]; P = .03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations.

Original language	English (US)
Pages (from-to)	1149-1153
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	192
Issue number	7
DOIs	https://doi.org/10.1086/444392
State	Published - Sep 1 2005

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/444392

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title = "Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults",

abstract = "We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up (odds ratio, 7 [95% confidence interval, 0.9-312]; P = .03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations.",

author = "Williams, {John V.} and Crowe, {James E.} and Rachel Enriquez and Patricia Minton and Peebles, {R. Stokes} and Hamilton, {Robert G.} and Stanley Higgins and Marie Griffin and Hartert, {Tina V.}",

note = "Funding Information: Financial support: National Institutes of Health (grant R03 AI 54790 to J.V.W. and grants KO8 AI 001582 and MO1 RR 00095 to T.V.H.); American Lung Association Clinical Research Grant (to T.V.H.).",

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AU - Crowe, James E.

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AU - Minton, Patricia

AU - Peebles, R. Stokes

AU - Hamilton, Robert G.

AU - Higgins, Stanley

AU - Griffin, Marie

AU - Hartert, Tina V.

N1 - Funding Information: Financial support: National Institutes of Health (grant R03 AI 54790 to J.V.W. and grants KO8 AI 001582 and MO1 RR 00095 to T.V.H.); American Lung Association Clinical Research Grant (to T.V.H.).

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AB - We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up (odds ratio, 7 [95% confidence interval, 0.9-312]; P = .03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations.

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Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults

Abstract

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