Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene

Sae Bom Jeon; Hyoeun Kim; Kyeong Hyeon Chun; Jaewon Oh; Chulan Kwon; Hyo Kyoung Choi; Sangwoo Kim; Hyoung Pyo Kim; In Cheol Kim; Jung Yoon Yoo; Sahng Wook Park; Seok Min Kang; Seung Hyun Lee

doi:10.1016/j.scr.2023.103048

Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene

Sae Bom Jeon, Hyoeun Kim, Kyeong Hyeon Chun, Jaewon Oh, Chulan Kwon, Hyo Kyoung Choi, Sangwoo Kim, Hyoung Pyo Kim, In Cheol Kim, Jung Yoon Yoo, Sahng Wook Park, Seok Min Kang, Seung Hyun Lee

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Cardiac muscle troponin T protein binds to tropomyosin and regulates the calcium-dependent actin–myosin interaction on thin filaments in cardiomyocytes. Recent genetic studies have revealed that TNNT2 mutations are strongly linked to dilated cardiomyopathy (DCM). In this study, we generated YCMi007-A, a human induced pluripotent stem cell (hiPSC) line from a DCM patient with a p. Arg205Trp mutation in the TNNT2 gene. The YCMi007-A cells show high expression of pluripotent markers, normal karyotype, and differentiation into three germ layers. Thus, YCMi007-A—an established iPSC—could be useful for the investigation of DCM.

Original language	English (US)
Article number	103048
Journal	Stem Cell Research
Volume	67
DOIs	https://doi.org/10.1016/j.scr.2023.103048
State	Published - Mar 2023

ASJC Scopus subject areas

Cell Biology
Developmental Biology

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Jeon, S. B., Kim, H., Chun, K. H., Oh, J., Kwon, C., Choi, H. K., Kim, S., Kim, H. P., Kim, I. C., Yoo, J. Y., Park, S. W., Kang, S. M., & Lee, S. H. (2023). Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene. Stem Cell Research, 67, Article 103048. https://doi.org/10.1016/j.scr.2023.103048

Jeon, SB, Kim, H, Chun, KH, Oh, J, Kwon, C, Choi, HK, Kim, S, Kim, HP, Kim, IC, Yoo, JY, Park, SW, Kang, SM & Lee, SH 2023, 'Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene', Stem Cell Research, vol. 67, 103048. https://doi.org/10.1016/j.scr.2023.103048

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title = "Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene",

abstract = "Cardiac muscle troponin T protein binds to tropomyosin and regulates the calcium-dependent actin–myosin interaction on thin filaments in cardiomyocytes. Recent genetic studies have revealed that TNNT2 mutations are strongly linked to dilated cardiomyopathy (DCM). In this study, we generated YCMi007-A, a human induced pluripotent stem cell (hiPSC) line from a DCM patient with a p. Arg205Trp mutation in the TNNT2 gene. The YCMi007-A cells show high expression of pluripotent markers, normal karyotype, and differentiation into three germ layers. Thus, YCMi007-A—an established iPSC—could be useful for the investigation of DCM.",

author = "Jeon, {Sae Bom} and Hyoeun Kim and Chun, {Kyeong Hyeon} and Jaewon Oh and Chulan Kwon and Choi, {Hyo Kyoung} and Sangwoo Kim and Kim, {Hyoung Pyo} and Kim, {In Cheol} and Yoo, {Jung Yoon} and Park, {Sahng Wook} and Kang, {Seok Min} and Lee, {Seung Hyun}",

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doi = "10.1016/j.scr.2023.103048",

language = "English (US)",

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AU - Jeon, Sae Bom

AU - Kim, Hyoeun

AU - Chun, Kyeong Hyeon

AU - Oh, Jaewon

AU - Kwon, Chulan

AU - Choi, Hyo Kyoung

AU - Kim, Sangwoo

AU - Kim, Hyoung Pyo

AU - Kim, In Cheol

AU - Yoo, Jung Yoon

AU - Park, Sahng Wook

AU - Kang, Seok Min

AU - Lee, Seung Hyun

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AB - Cardiac muscle troponin T protein binds to tropomyosin and regulates the calcium-dependent actin–myosin interaction on thin filaments in cardiomyocytes. Recent genetic studies have revealed that TNNT2 mutations are strongly linked to dilated cardiomyopathy (DCM). In this study, we generated YCMi007-A, a human induced pluripotent stem cell (hiPSC) line from a DCM patient with a p. Arg205Trp mutation in the TNNT2 gene. The YCMi007-A cells show high expression of pluripotent markers, normal karyotype, and differentiation into three germ layers. Thus, YCMi007-A—an established iPSC—could be useful for the investigation of DCM.

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Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C > T (p. Arg205Trp) variant of the TNNT2 gene

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