Human immunodeficiency virus type 1-specific immunity after genetic immunization is enhanced by modification of Gag and Pol expression

Y. Huang; W. P. Kong; G. J. Nabel

doi:10.1128/JVI.75.10.4947-4951.2001

Human immunodeficiency virus type 1-specific immunity after genetic immunization is enhanced by modification of Gag and Pol expression

Y. Huang, W. P. Kong, G. J. Nabel

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104 Scopus citations

Abstract

Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial Pol responses. This fusion protein may be useful for AIDS vaccines.

Original language	English (US)
Pages (from-to)	4947-4951
Number of pages	5
Journal	Journal of Virology
Volume	75
Issue number	10
DOIs	https://doi.org/10.1128/JVI.75.10.4947-4951.2001
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1128/JVI.75.10.4947-4951.2001

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abstract = "Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial Pol responses. This fusion protein may be useful for AIDS vaccines.",

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AB - Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial Pol responses. This fusion protein may be useful for AIDS vaccines.

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Human immunodeficiency virus type 1-specific immunity after genetic immunization is enhanced by modification of Gag and Pol expression

Abstract

ASJC Scopus subject areas

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