Human granulocyte collagenase

Gerald S. Lazarus, Robert S. Brown, John R. Daniels, Harold M. Fullmer

Research output: Contribution to journalArticlepeer-review

221 Scopus citations


A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.

Original languageEnglish (US)
Pages (from-to)1483-1485
Number of pages3
Issue number3822
StatePublished - 1968
Externally publishedYes

ASJC Scopus subject areas

  • General


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