Human correlates of provocative questions in pancreatic pathology

Oliver G. McDonald, Anirban Maitra, Ralph H. Hruban

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Studies of cell lines and of animal models of pancreatic cancer have raised a number of provocative questions about the nature and origins of human pancreatic cancer and have provided several leads into exciting new approaches for the treatment of this deadly cancer. In addition, clinicians with little or no contact with human pathology have challenged the way that pancreatic pathology is practiced, suggesting that "genetic signals" may be more accurate than today's multimodal approach to diagnoses. In this review, we consider 8 provocative issues in pancreas pathology, with an emphasis on "the evidence derived from man."

Original languageEnglish (US)
Pages (from-to)351-362
Number of pages12
JournalAdvances in anatomic pathology
Issue number6
StatePublished - Nov 2012


  • Epithelial-mesenchymal transition
  • Metastasis
  • Pancreas
  • Pancreatic cancer
  • Stroma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine


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