Human caliciviruses as a cause of severe gastroenteritis in Peruvian children

Umesh D. Parashar; Jin Fen Li; Rosa Cama; Mark DeZalia; Stephan S. Monroe; David N. Taylor; Dante Figueroa; Robert H. Gilman; Roger I. Glass

doi:10.1086/423324

Human caliciviruses as a cause of severe gastroenteritis in Peruvian children

Umesh D. Parashar, Jin Fen Li, Rosa Cama, Mark DeZalia, Stephan S. Monroe, David N. Taylor, Dante Figueroa, Robert H. Gilman, Roger I. Glass

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

To define the role of human caliciviruses (HuCVs) in severe childhood gastroenteritis, fecal and paired serum samples from 233 Peruvian children hospitalized with gastroenteritis (case patients) and fecal samples from 248 control subjects were evaluated. Overall, 128 case patients (55%) demonstrated HuCV infection by either fecal (n = 81 [35%]) or serological (n = 96 [41%]) testing. HuCVs were more prevalent in fecal samples from case patients than those from control subjects (35% vs. 13%; P < .001). HuCV infection was more prevalent among case patients without another pathogen than in those who had a coinfecting pathogen (77% [40/52] vs. 49% [88/181]; P < .001). HuCVs appear to be an important cause of gastroenteritis in Peruvian children.

Original language	English (US)
Pages (from-to)	1088-1092
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	190
Issue number	6
DOIs	https://doi.org/10.1086/423324
State	Published - Sep 15 2004

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/423324

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title = "Human caliciviruses as a cause of severe gastroenteritis in Peruvian children",

abstract = "To define the role of human caliciviruses (HuCVs) in severe childhood gastroenteritis, fecal and paired serum samples from 233 Peruvian children hospitalized with gastroenteritis (case patients) and fecal samples from 248 control subjects were evaluated. Overall, 128 case patients (55%) demonstrated HuCV infection by either fecal (n = 81 [35%]) or serological (n = 96 [41%]) testing. HuCVs were more prevalent in fecal samples from case patients than those from control subjects (35% vs. 13%; P < .001). HuCV infection was more prevalent among case patients without another pathogen than in those who had a coinfecting pathogen (77% [40/52] vs. 49% [88/181]; P < .001). HuCVs appear to be an important cause of gastroenteritis in Peruvian children.",

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AU - Parashar, Umesh D.

AU - Li, Jin Fen

AU - Cama, Rosa

AU - DeZalia, Mark

AU - Monroe, Stephan S.

AU - Taylor, David N.

AU - Figueroa, Dante

AU - Gilman, Robert H.

AU - Glass, Roger I.

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AB - To define the role of human caliciviruses (HuCVs) in severe childhood gastroenteritis, fecal and paired serum samples from 233 Peruvian children hospitalized with gastroenteritis (case patients) and fecal samples from 248 control subjects were evaluated. Overall, 128 case patients (55%) demonstrated HuCV infection by either fecal (n = 81 [35%]) or serological (n = 96 [41%]) testing. HuCVs were more prevalent in fecal samples from case patients than those from control subjects (35% vs. 13%; P < .001). HuCV infection was more prevalent among case patients without another pathogen than in those who had a coinfecting pathogen (77% [40/52] vs. 49% [88/181]; P < .001). HuCVs appear to be an important cause of gastroenteritis in Peruvian children.

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Human caliciviruses as a cause of severe gastroenteritis in Peruvian children

Abstract

ASJC Scopus subject areas

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