HPV self-sampling for cervical cancer screening: A systematic review of values and preferences

Holly Nishimura, Ping Teresa Yeh, Habibat Oguntade, Caitlin E. Kennedy, Manjulaa Narasimhan

Research output: Contribution to journalArticlepeer-review


Introduction The WHO recommends human papillomavirus (HPV) cervical self-sampling as an additional screening method and HPV DNA testing as an effective approach for the early detection of cervical cancer for women aged ≥30 years. This systematic review assesses end user's values and preferences related to HPV self-sampling. Methods We searched four electronic databases (PubMed, Cumulative Index to Nursing and Allied Health Literature, Latin American and Caribbean Health Sciences Literature and Embase) using search terms for HPV and self-sampling to identify articles meeting inclusion criteria. A standardised data extraction form was used to capture study setting, population, sample size and results related to values and preferences. Results Of 1858 records retrieved, 72 studies among 52 114 participants published between 2002 and 2018 were included in this review. Almost all studies were cross-sectional surveys. Study populations included end users who were mainly adolescent girls and adult women. Ages ranged from 14 to 80 years. Most studies (57%) were conducted in high-income countries. Women generally found HPV self-sampling highly acceptable regardless of age, income or country of residence. Lack of self-confidence with collecting a reliable sample was the most commonly cited reason for preferring clinician-collected samples. Most women preferred home-based self-sampling to self-sampling at a clinic. The cervical swab was the most common and most accepted HPV DNA sampling device. Conclusions HPV self-sampling is generally a highly accepted method of cervical cancer screening for end users globally. End user preferences for self-sampling device, method and setting can inform the development of new and expanded interventions to increase HPV screening.

Original languageEnglish (US)
Article numbere003743
JournalBMJ Global Health
Issue number5
StatePublished - May 19 2021


  • cancer
  • disease
  • disorder
  • or injury
  • other infection
  • public health
  • systematic review

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health Policy


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