How to participate in a multiple sclerosis clinical trial

J. A. Frank, H. F. McFarland

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


MR imaging has made significant and important contributions in the understanding of the natural history of multiple sclerosis. The role of MR imaging and its importance in clinical trials will continue to increase over the next years, not only as a secondary outcome measure in pivotal trials but also as a method of monitoring therapeutic responses in early phase trials. As we move forward in our understanding of the underlying pathophysiology and immunology of MS, correlation with MR imaging measures of disease activity will be essential to translate from the research bench to the patient's bedside, and to use MR imaging more effectively in treatment trials. Neuroimaging groups can provide the required expertise and work together with both clinicians and the pharmaceutical companies in designing MS treatment trials that incorporate clinical and MR imaging outcome measures to determine the effectiveness and long-term benefits to patients of new treatments for MS.

Original languageEnglish (US)
Pages (from-to)817-830
Number of pages14
JournalNeuroimaging Clinics of North America
Issue number4
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology


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