How to evaluate the efficacy of the phosphodiesterase type 5 inhibitors

Emmanuele A. Jannini, Leonard R. Derogatis, Eric Chung, Gerald B. Brock

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Introduction. Several methods have been so far proposed to compare the effectiveness of the three available phosphodiesterase type 5 inhibitors (PDE5Is). Methods. Two urologists (E.C. and G.B.B.), together with the Controversy's Editor (E.A.J.), with expertise in the area of medical treatment of erectile dysfunction (ED) present the various perspectives on the evaluation of PDE5Is in ED. The use of the most popular psychometric tool, the International Index of Erectile Function, is presented by an expert psychologist (L.R.D.). Main Outcome Measures. Expert opinion supported by the critical review of the currently available literature. Results. Trials have demonstrated that the PDE5Is are excellent drugs with a great specificity of action and an almost perfect tolerance profile. Some instruments for comparison of clinical efficacy have to be considered subjective (psychometry, patient's preference, changes in quality of general, or sexual life). Some others are more objective (hardness, hormonal levels, and local circulation). An evidence-based comparison of the three PDE5Is should in the future be rooted in both subjective and objective methods. This will be of paramount importance in the drug trial design of new, forthcoming PDE5Is. Conclusions. Comparison between PDE5Is using both subjective and objective parameters will permit to individuate, on the basis of the evidence, the subset of couples where one drug, or one dose, or dose regimen, is to be considered of first choice.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalJournal of Sexual Medicine
Issue number1
StatePublished - Jan 2012


  • Erectile Dysfunction
  • Sildenafil
  • Tadalafil
  • Treatment
  • Vardenafil

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Psychiatry and Mental health
  • Urology


Dive into the research topics of 'How to evaluate the efficacy of the phosphodiesterase type 5 inhibitors'. Together they form a unique fingerprint.

Cite this