How HLA-DM molecules work: Recognition of MHC II conformational heterogeneity

Scheherazade Sadegh-Nasseri; Chih Ling Chou; Isamu Z. Hartman; Aeryon Kim; Kedar Narayan

doi:10.2741/s334

How HLA-DM molecules work: Recognition of MHC II conformational heterogeneity

Scheherazade Sadegh-Nasseri, Chih Ling Chou, Isamu Z. Hartman, Aeryon Kim, Kedar Narayan

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Helper T cells respond to peptide antigens derived from exogenous sources presented by MHC II on antigen presenting cells. Antigens from pathogens are internalized by professional antigen presenting cells (APC) and processed for presentation. Certain epitopes are selected during processing as the final peptides for stimulation of T cells and are termed "immunodominant". Understanding how selection of immunodominant epitopes takes place has been a difficult task because of the complexity of the mechanisms governing both antigen processing and T cell recognition. In this review, we discuss our current understanding of HLA-DM function in peptide exchange and selection and its relevance to epitope immunodominance.

Original language	English (US)
Pages (from-to)	1325-1332
Number of pages	8
Journal	Frontiers in Bioscience - Scholar
Volume	4 S
Issue number	4
DOIs	https://doi.org/10.2741/s334
State	Published - Jun 1 2012

Keywords

Antigen presentation
Antigen processing
Conformational heterogeneity
Epitope selection
HLA-DM
HLA-DR
Immunodominance
MHC class II
Molecular recognition
Review

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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10.2741/s334

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abstract = "Helper T cells respond to peptide antigens derived from exogenous sources presented by MHC II on antigen presenting cells. Antigens from pathogens are internalized by professional antigen presenting cells (APC) and processed for presentation. Certain epitopes are selected during processing as the final peptides for stimulation of T cells and are termed {"}immunodominant{"}. Understanding how selection of immunodominant epitopes takes place has been a difficult task because of the complexity of the mechanisms governing both antigen processing and T cell recognition. In this review, we discuss our current understanding of HLA-DM function in peptide exchange and selection and its relevance to epitope immunodominance.",

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AU - Kim, Aeryon

AU - Narayan, Kedar

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AB - Helper T cells respond to peptide antigens derived from exogenous sources presented by MHC II on antigen presenting cells. Antigens from pathogens are internalized by professional antigen presenting cells (APC) and processed for presentation. Certain epitopes are selected during processing as the final peptides for stimulation of T cells and are termed "immunodominant". Understanding how selection of immunodominant epitopes takes place has been a difficult task because of the complexity of the mechanisms governing both antigen processing and T cell recognition. In this review, we discuss our current understanding of HLA-DM function in peptide exchange and selection and its relevance to epitope immunodominance.

KW - Antigen presentation

KW - Antigen processing

KW - Conformational heterogeneity

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KW - Molecular recognition

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How HLA-DM molecules work: Recognition of MHC II conformational heterogeneity

Abstract

Keywords

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