How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center

John O. Clarke, Samuel A. Giday, Priscilla Magno, Eun Ji Shin, Jonathan M. Buscaglia, Sanjay B. Jagannath, Gerard E. Mullin

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Background: Ampullary adenomas are increasingly being recognized, particularly in patients with familial adenomatous polyposis. A capsule endoscopy (CE) is routinely recommended for surveillance of small-intestinal polyposis. Performance characteristics of CE for the detection of periampullary lesions are unclear. Objective: To evaluate the ability of CE to detect the major duodenal papilla. Design and Patients: A total of 146 consecutive CE studies were reviewed by 2 CE gastroenterologists at 5 frames per second. Primary outcome was visualization of the major duodenal papilla. Discrepancies were reviewed by 5 CE gastroenterologists. Setting: A tertiary-referral center. Main Outcome Measurements: The ability of CE to detect the duodenal papilla. Results: Among 146 consecutive CE studies, 21 were excluded: capsule retention (3), patient age <18 years (6), duplicate study (8), and prior surgery disrupting duodenal anatomy (4). Of the remaining 125 studies, indications were the following: obscure GI bleeding (45.6%), iron deficiency anemia (19.2%), abdominal pain (17.6%), diarrhea (10.4%), and Crohn's disease (4.8%). In total, 13 major duodenal papillae were visualized. The median time of detection was 31 seconds after the first duodenal image. This translates to a CE sensitivity of 10.4% for detection of the major papilla. Limitation: Papilla position was not verified by an EGD. Conclusions: CE has limited sensitivity to visualize the major papilla and lesions in the periampullary small intestine. Nondiagnostic CE studies must not be relied upon as proof that small-bowel lesions do not exist. Consideration should be given for an enteroscopy or side-viewing duodenoscopy in cases where significant clinical concern exists for unrecognized periampullary lesions. The current recommendations about surveillance for small-bowel polyposis should be revised.

Original languageEnglish (US)
Pages (from-to)267-272
Number of pages6
JournalGastrointestinal endoscopy
Issue number2
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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