How does Anopheles gambiae kill malaria parasites?

G. Dimopoulos, H. M. Müller, F. C. Kafatos

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The malaria parasite's lifecycle in the mosquito vector Anopheles gambiae involves several translocations within and between tissues during which large parasite losses have been documented. Interestingly, during the critical transition stages of midgut invasion and relocation of sporozoites from the oocysts to the salivary glands the mosquito innate immune system is activated. These defense reactions could, at least partially, be responsible for the parasite killing in the mosquito. This important question is now being approached by the dissection of the mosquito innate immune system as well as genetic and genomic studies.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
Issue number1-3
StatePublished - Sep 1999
Externally publishedYes


  • Anopheles gambiae
  • Innate immunity
  • Malaria

ASJC Scopus subject areas

  • Parasitology


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