How accurate is ceftriaxone at predicting susceptibility of enterobacterales isolates to oral higher-generation cephalosporins?

Kimberly C. Claeys; Patricia J. Simner; Tsigereda Tekle; Anthony D. Harris; Emily Jacobs; Sara E. Cosgrove; Pranita D. Tamma

doi:10.1128/aac.01387-24

How accurate is ceftriaxone at predicting susceptibility of enterobacterales isolates to oral higher-generation cephalosporins?

Kimberly C. Claeys, Patricia J. Simner, Tsigereda Tekle, Anthony D. Harris, Emily Jacobs, Sara E. Cosgrove, Pranita D. Tamma

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The reliability of ceftriaxone for inferring susceptibility to higher-generation oral cephalosporins is unknown. Overall, ceftriaxone susceptibility predicted susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime (90%), and cefixime (94%) based on disk diffusion results for 409 consecutive Enterobacterales bloodstream isolates from unique patients. Susceptibility percentages to the four oral cephalosporins ranged from 92% to 99% when limited to Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, or Proteus mirabilis isolates susceptible to ceftriaxone.

Original language	English (US)
Journal	Antimicrobial agents and chemotherapy
Volume	69
Issue number	2
DOIs	https://doi.org/10.1128/aac.01387-24
State	Published - Feb 2025

Keywords

cefdinir
cefixime
cefpodoxime
ceftriaxone
cefuroxime

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/aac.01387-24

Cite this

@article{ff510699352c4afb8ddd960f11c1789f,

title = "How accurate is ceftriaxone at predicting susceptibility of enterobacterales isolates to oral higher-generation cephalosporins?",

abstract = "The reliability of ceftriaxone for inferring susceptibility to higher-generation oral cephalosporins is unknown. Overall, ceftriaxone susceptibility predicted susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime (90%), and cefixime (94%) based on disk diffusion results for 409 consecutive Enterobacterales bloodstream isolates from unique patients. Susceptibility percentages to the four oral cephalosporins ranged from 92% to 99% when limited to Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, or Proteus mirabilis isolates susceptible to ceftriaxone.",

keywords = "cefdinir, cefixime, cefpodoxime, ceftriaxone, cefuroxime",

author = "Claeys, {Kimberly C.} and Simner, {Patricia J.} and Tsigereda Tekle and Harris, {Anthony D.} and Emily Jacobs and Cosgrove, {Sara E.} and Tamma, {Pranita D.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2024 Claeys et al.",

year = "2025",

month = feb,

doi = "10.1128/aac.01387-24",

language = "English (US)",

volume = "69",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",