Hormone levels before and after tubal sterilization

Gwen P. Gentile, Donald W. Helbig, Howard Zacur, Taesung Park, Young Jack Lee, Carolyn L. Westhoff

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: The aim of this study was to determine whether women experience significant luteal phase hormonal changes following interval tubal sterilization. Design: This is a partly randomized, prospective clinical study. Setting: This study involved healthy volunteers in an academic research environment. Patients: This study involved 118 fertile women seeking tubal sterilization and 57 fertile controls with at least three normal cyclic menstrual periods before entry into the study. Interventions: The patients were randomized to bipolar cautery or Hulka clip as sterilization methods. Barrier contraception or abstinence was used by controls. Main Outcome Measures: The main outcome measures are serum estradiol and progesterone levels and urinary estradiol and pregnanediol levels obtained during the luteal phase before, 1 year and 2 years after sterilization. Results: The women randomized to the bipolar cautery group had higher midluteal progesterone levels measured between Days 5 and 11 postovulation (15.5 ng/mL before sterilization, 14.5 ng/mL at 1 year and 14.5 ng/mL at 2 years) than did the other two groups. The clip group had progesterone levels of 14.1, 12.0 and 12.5 ng/mL at baseline, 1 year and 2 years, respectively, and the control group had levels of 12.0, 11.9 and 11.3 ng/mL for the same periods. Serum estradiol and progesterone and urinary pregnanediol and estradiol were not significantly changed over the 2-year period, nor were there significant differences between the two groups. Conclusions: There were no significant hormonal changes in sterilized women over a period of 2 years when compared with their baseline levels or when compared with unsterilized age-matched controls.

Original languageEnglish (US)
Pages (from-to)507-511
Number of pages5
Issue number5
StatePublished - May 2006


  • Bipolar tubal cauterization
  • Estradiol level
  • Hulka clip sterilization
  • Laparoscopic tubal sterilization
  • Luteal phase hormonal levels
  • Posttubal sterilization syndrome
  • Progesterone level

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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