Hormone and hormonal agents in the treatment of aggression

Dietrich Blumer, Claude Migeon

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Evidence for the role of androgens in the male aggressive and sexual behavior is reviewed. Medroxyprogesterone acetate (MPA; Provera, Upjohn) has a marked antiandrogen property; it is effective in lowering the testosterone level and controlling certain otherwise intractable sex deviations. The finding in 6 patients treated for sex deviation are summarized. The effects of MPA in the treatment of 11 temporal lobe epileptics and 5 other patients with severe angry-aggressive behavior disorder are reported. Most temporal lobe epileptics responded well to MPA. Weight gain and earlier sleep were consistent side effects. The values of plasma testosterone, serum luteinizing hormone, and urinary 17-ketosteroids were decreased by the treatment. Pour patients were XYY individuals with lack of control over their sexual-aggressive or angry-aggressive impulses.

Original languageEnglish (US)
Pages (from-to)127-137
Number of pages11
JournalJournal of Nervous and Mental Disease
Issue number2
StatePublished - Feb 1975

ASJC Scopus subject areas

  • Psychiatry and Mental health


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