TY - JOUR
T1 - Hormonal responses to physical exercise in patients with polycystic ovarian syndrome
AU - Jaatinen, T. A.
AU - Anttila, L.
AU - Erkkola, R.
AU - Koskinen, P.
AU - Laippala, P.
AU - Ruutiainen, K.
AU - Scheinin, M.
AU - Irjala, K.
N1 - Funding Information:
Received December 24, 1992; revised and accepted April 6, 1993. * Supported by grants from the Emil Aaltonen Foundation, Tampere, Finnish Gynecological Association, Helsinki, and the Paulo Foundation, Helsinki, Finland. t Department of Obstetrics and Gynecology, University Central Hospital of Turku. :j: Reprint requests: Tuula-Anneli Jaatinen, M.D., Department of Obstetrics and Gynecology, University Central Hospital of Turku, Kiinamyllynkatu 4-8, SF -20520 Turku, Finland. § Department of Clinical Chemistry, University Central Hospital of Turku. II Department of Public Health/Biometry Unit, University of Tampere.
PY - 1993
Y1 - 1993
N2 - Objective: To examine the effects of obesity and polycystic ovarian syndrome (PCOS) on the endocrine responses to physical exercise. Setting: Outpatient clinic of reproductive endocrinology at the University Central Hospital of Turku and the Department of Pharmacology, University of Turku, Turku, Finland. Patients: Nine oligomenorrheic women with PCOS (body mass index [BMI] 19.5 to 46.0 kg/m2) and eight control women with regular menstrual cycles (BMI 20.0 to 53.5 kg/m2). Interventions: A bicycle ergometer test was performed at 8 A.M. Results: The only hormone response that was different between PCOS patients and controls was the exercise- induced increase in circulating GH levels. This response was significantly greater in controls than in PCOS patients. There was also a negative correlation between the GH response and BMI. The increases in the concentrations of adrenaline, noradrenaline, 3,4-dihydroxyphenylglycol, glucose, and insulin:C-peptide ratios during the bicycle ergometer test were correlated negatively to BMI. Conclusion: Obesity is an important determinant of the hormonal responses to physical exercise. This applies also to women with PCOS. Taking obesity into account in the analysis of exercise-induced hormone responses, only little, if any, of the variation in the hormonal responses measured by us could be attributed to PCOS per se. The only hormone response that was different between PCOS patients and controls was the GH response.
AB - Objective: To examine the effects of obesity and polycystic ovarian syndrome (PCOS) on the endocrine responses to physical exercise. Setting: Outpatient clinic of reproductive endocrinology at the University Central Hospital of Turku and the Department of Pharmacology, University of Turku, Turku, Finland. Patients: Nine oligomenorrheic women with PCOS (body mass index [BMI] 19.5 to 46.0 kg/m2) and eight control women with regular menstrual cycles (BMI 20.0 to 53.5 kg/m2). Interventions: A bicycle ergometer test was performed at 8 A.M. Results: The only hormone response that was different between PCOS patients and controls was the exercise- induced increase in circulating GH levels. This response was significantly greater in controls than in PCOS patients. There was also a negative correlation between the GH response and BMI. The increases in the concentrations of adrenaline, noradrenaline, 3,4-dihydroxyphenylglycol, glucose, and insulin:C-peptide ratios during the bicycle ergometer test were correlated negatively to BMI. Conclusion: Obesity is an important determinant of the hormonal responses to physical exercise. This applies also to women with PCOS. Taking obesity into account in the analysis of exercise-induced hormone responses, only little, if any, of the variation in the hormonal responses measured by us could be attributed to PCOS per se. The only hormone response that was different between PCOS patients and controls was the GH response.
KW - Polycystic ovarian syndrome
KW - bicycle ergometer
KW - obesity
KW - stress hormone responses
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U2 - 10.1016/s0015-0282(16)56094-4
DO - 10.1016/s0015-0282(16)56094-4
M3 - Article
C2 - 8339821
AN - SCOPUS:0027220291
SN - 0015-0282
VL - 60
SP - 262
EP - 267
JO - Fertility and sterility
JF - Fertility and sterility
IS - 2
ER -