Hormonal contraception and HIV acquisition: Reanalysis using marginal structural modeling

Charles S. Morrison, Pai Lien Chen, Cynthia Kwok, Barbra A. Richardson, Tsungai Chipato, Roy Mugerwa, Josaphat Byamugisha, Nancy Padian, David D. Celentano, Robert A. Salata

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.

Original languageEnglish (US)
Pages (from-to)1778-1781
Number of pages4
Issue number11
StatePublished - Jul 17 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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