Homer as both a scaffold and transduction molecule.

Laurent Fagni, Paul F. Worley, Fabrice Ango

Research output: Contribution to journalReview articlepeer-review

118 Scopus citations


Increasing evidence shows that scaffold proteins not only control membrane assembly of receptors and channels, but also modulate intracellular signaling by assembled receptors. The Homer family of proteins act as scaffolds to bind clusters of proteins and glutamate receptors at postsynaptic sites. We review results of cloning and gene expression of this protein family, and summarize roles in glutamate receptor function and intracellular signaling in neurons. Homer proteins trigger the localization of metabotropic glutamate receptor subtype 5 (mGlu5 receptor) to the postsynaptic plasma membrane. They can also alter the kinetics and peak amplitude of the intracellular Ca2+ responses of mGlu1 and mGlu5 receptors. Homer proteins can either prevent or promote spontaneous activation of these receptors, depending on the type of Homer protein isoform expressed.

Original languageEnglish (US)
Pages (from-to)RE8
JournalScience's STKE : signal transduction knowledge environment
Issue number137
StatePublished - Jun 18 2002
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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