Home Introduction of Baked Egg After Oral Food Challenge

Mansi Kotwal, Ammara Ahmed, Jaqueline Isola, Jennifer A. Dantzer, Corinne Keet, Joan H. Dunlop, Robert A. Wood

Research output: Contribution to journalArticlepeer-review


Background: Baked egg (BE) introduction may accelerate resolution of egg allergy. Long-term data regarding the safety and success of BE introduction in the real world are limited. Objective: To identify predictors of future egg consumption and barriers to advancement based on characteristics during and after BE oral food challenges (OFCs). Methods: We performed a retrospective review of consecutive BE OFCs with a minimum 24-month follow-up. Goal doses ranged from 1/16 to 1/4 egg. Outcomes were categorized as pass (no reaction), fail (but allowed BE introduction), or fail (avoid). Status of egg introduction and reactions were recorded. Results: A total of 243 patients were included; 134 passed and 109 failed (70 of whom were instructed to introduce BE). At follow-up (median, 47 months), 90 (37%) were consuming direct egg, 26 (11%) lightly cooked egg, 39 (16%) BE, and 88 (36%) avoiding; 58% who failed versus 81% who passed were consuming some form of egg. Median egg white IgE level was significantly higher among avoiders versus introducers (8.7 vs 5.8; P =.008). Lower egg white IgE level and younger age were predictors of egg consumption in some form at follow-up (median IgE, 5.8 vs 8.4; P =.03; median age, 4.0 vs 8.0 years; P <.001). A total of 94 patients had a total of 136 reactions (132 mild, 4 severe); 22 (16.2%) were accidental exposures, 42 (30.9%) planned escalations, and 72 (52.9%) with previously tolerated doses. Conclusions: Most patients who underwent a BE OFC continued to consume some form of egg, often advancing to direct egg. However, many reverted to avoidance and adverse reactions were common.

Original languageEnglish (US)
Pages (from-to)274-280.e2
JournalJournal of Allergy and Clinical Immunology: In Practice
Issue number1
StatePublished - Jan 2023


  • Baked egg
  • Egg White IgE
  • Egg allergy
  • Food allergy
  • Oral food challenge

ASJC Scopus subject areas

  • Immunology and Allergy


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