HLA-DR expression by labial minor salivary gland tissues in Sjogren's syndrome

H. M. Moutsopoulos, J. J. Hooks, C. C. Chan, Y. A. Dalavanga, F. N. Skopouli, B. Detrick

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Minor salivary gland biopsy specimens from patients with Sjogren's syndrome (primary and secondary) and from normal controls were examined with the four step biotinavidin-immunoperoxidase assay. The composition of the infiltrating cells was similar in patients with both primary and secondary Sjogren's syndrome, consisting primarily of T lymphocytes with predominance of T helper/inducer cells. B lymphocytes (Leu-14) were approximately 20-35% of the infiltrating lymphocytes, while only a few OKM1 (monocytes/macrophages) cells and Leu-7+ (natural killer; NK) cells were observed. The majority of infiltrating lymphocytes expressed HLA-DR antigens. In the biopsy specimens of the controls there were no infiltrates; the scattered lymphocytes, however, were also predominantly T lymphocytes. Finally, the glandular epithelial cells (ducts and acini) were inappropriately expressing HLA-DR antigens, in contrast with controls where minimal HLA-DR expression was found.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalAnnals of the rheumatic diseases
Issue number8
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • General Biochemistry, Genetics and Molecular Biology


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