HLA class I and II typing of the patients with Behcet's disease in Saudi Arabia

K. Yabuki, S. Ohno, N. Mizuki, H. Ando, K. F. Tabbara, K. Goto, E. Nomura, S. Nakamura, N. Ito, M. Ota, Y. Katsuyama, Hidetoshi Inoko

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Thirteen Saudi Arabian patients with Behcet's disease (BD) were typed for HLA-A and -B alleles by the conventional serologic typing and for HLA-DRB1, -DQB1 and -DPB1 alleles by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. As a result, the phenotype frequency of the B51 antigen was significantly increased in the patient group as compared to the ethnically matched control group (76.9% in patients vs. 22.2% in controls), but no significant difference was observed in HLA-A, -DRB1, -DQB1 or -DPB1 alleles between the patients and controls, as previously observed in Japanese BD. Further, by HLA-B51 allelic genotyping performed by the polymerase chain reaction-sequence specific primers (PCR-SSP) method, all of the B51-positive patients and controls were found to carry one particular allele, B*5101, except one patient with B*5108.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalTissue Antigens
Issue number3
StatePublished - 1999
Externally publishedYes


  • B51
  • Behcet's disease
  • Genotyping
  • HLA
  • Saudi Arabian

ASJC Scopus subject areas

  • Immunology
  • Cell Biology


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