Abstract
Thirteen Saudi Arabian patients with Behcet's disease (BD) were typed for HLA-A and -B alleles by the conventional serologic typing and for HLA-DRB1, -DQB1 and -DPB1 alleles by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. As a result, the phenotype frequency of the B51 antigen was significantly increased in the patient group as compared to the ethnically matched control group (76.9% in patients vs. 22.2% in controls), but no significant difference was observed in HLA-A, -DRB1, -DQB1 or -DPB1 alleles between the patients and controls, as previously observed in Japanese BD. Further, by HLA-B51 allelic genotyping performed by the polymerase chain reaction-sequence specific primers (PCR-SSP) method, all of the B51-positive patients and controls were found to carry one particular allele, B*5101, except one patient with B*5108.
Original language | English (US) |
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Pages (from-to) | 273-277 |
Number of pages | 5 |
Journal | Tissue Antigens |
Volume | 54 |
Issue number | 3 |
DOIs | |
State | Published - 1999 |
Externally published | Yes |
Keywords
- B51
- Behcet's disease
- Genotyping
- HLA
- PCR-SSP
- Saudi Arabian
ASJC Scopus subject areas
- Immunology
- Cell Biology