Abstract
In 1958, Professors Jean Dausset, Jon van Rood, and Rose Payne detected and reported on what were the first HLA antibodies. In 1964, Dr. Bernard Amos organized the first International Histocompatibility where 23 pioneering investigators participated in a "wet workshop" to study HLA antigens and antibodies. There have since been 16 additional workshops, all designed to confirm scientific observations; develop unifying concepts regarding the major histocompatibility complex (MHC), and update HLA nomenclature. The MHC region, located on chromosome 6, represents one of the most polymorphic regions in all of the human genome. The HLA system is the most polymorphic genetic system known to exist in humans. The number of different phenotypes possible from all combinations of HLA alleles is greater than the global population. In recent years, focus in the field of histocompatibility has shifted from the antigens and alleles to epitopes and eplets.
| Original language | English (US) |
|---|---|
| Title of host publication | Rossi's Principles of Transfusion Medicine |
| Publisher | wiley |
| Pages | 624-632 |
| Number of pages | 9 |
| ISBN (Electronic) | 9781119719793 |
| ISBN (Print) | 9781119719755 |
| DOIs | |
| State | Published - Jul 10 2022 |
Keywords
- HLA alleles
- HLA antibodies
- HLA antigens
- Major histocompatibility complex
- Polymorphic genetic system
ASJC Scopus subject areas
- General Medicine