HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection

Salim I. Khakoo; Chloe L. Thio; Maureen P. Martin; Collin R. Brooks; Xiaojiang Gao; Jacquie Astemborski; Jie Cheng; James J. Goedert; David Vlahov; Margaret Hilgartner; Steven Cox; Ann Margeret Little; Graeme J. Alexander; Matthew E. Cramp; Stephen J. O'Brien; William M.C. Rosenberg; David L. Thomas; Mary Carrington

doi:10.1126/science.1097670

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection

Salim I. Khakoo, Chloe L. Thio, Maureen P. Martin, Collin R. Brooks, Xiaojiang Gao, Jacquie Astemborski, Jie Cheng, James J. Goedert, David Vlahov, Margaret Hilgartner, Steven Cox, Ann Margeret Little, Graeme J. Alexander, Matthew E. Cramp, Stephen J. O'Brien, William M.C. Rosenberg, David L. Thomas, Mary Carrington

School of Medicine

Research output: Contribution to journal › Article › peer-review

915 Scopus citations

Abstract

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

Original language	English (US)
Pages (from-to)	872-874
Number of pages	3
Journal	Science
Volume	305
Issue number	5685
DOIs	https://doi.org/10.1126/science.1097670
State	Published - Aug 6 2004

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1097670

Cite this

Khakoo, S. I., Thio, C. L., Martin, M. P., Brooks, C. R., Gao, X., Astemborski, J., Cheng, J., Goedert, J. J., Vlahov, D., Hilgartner, M., Cox, S., Little, A. M., Alexander, G. J., Cramp, M. E., O'Brien, S. J., Rosenberg, W. M. C., Thomas, D. L., & Carrington, M. (2004). HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science, 305(5685), 872-874. https://doi.org/10.1126/science.1097670

Khakoo, SI, Thio, CL, Martin, MP, Brooks, CR, Gao, X, Astemborski, J, Cheng, J, Goedert, JJ, Vlahov, D, Hilgartner, M, Cox, S, Little, AM, Alexander, GJ, Cramp, ME, O'Brien, SJ, Rosenberg, WMC, Thomas, DL & Carrington, M 2004, 'HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection', Science, vol. 305, no. 5685, pp. 872-874. https://doi.org/10.1126/science.1097670

@article{cad85b08cb8b47a0a845c3fdda645d84,

title = "HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection",

abstract = "Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.",

author = "Khakoo, {Salim I.} and Thio, {Chloe L.} and Martin, {Maureen P.} and Brooks, {Collin R.} and Xiaojiang Gao and Jacquie Astemborski and Jie Cheng and Goedert, {James J.} and David Vlahov and Margaret Hilgartner and Steven Cox and Little, {Ann Margeret} and Alexander, {Graeme J.} and Cramp, {Matthew E.} and O'Brien, {Stephen J.} and Rosenberg, {William M.C.} and Thomas, {David L.} and Mary Carrington",

year = "2004",

month = aug,

day = "6",

doi = "10.1126/science.1097670",

language = "English (US)",

volume = "305",

pages = "872--874",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5685",

}

TY - JOUR

T1 - HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection

AU - Khakoo, Salim I.

AU - Thio, Chloe L.

AU - Martin, Maureen P.

AU - Brooks, Collin R.

AU - Gao, Xiaojiang

AU - Astemborski, Jacquie

AU - Cheng, Jie

AU - Goedert, James J.

AU - Vlahov, David

AU - Hilgartner, Margaret

AU - Cox, Steven

AU - Little, Ann Margeret

AU - Alexander, Graeme J.

AU - Cramp, Matthew E.

AU - O'Brien, Stephen J.

AU - Rosenberg, William M.C.

AU - Thomas, David L.

AU - Carrington, Mary

PY - 2004/8/6

Y1 - 2004/8/6

N2 - Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

AB - Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

UR - http://www.scopus.com/inward/record.url?scp=3843075120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3843075120&partnerID=8YFLogxK

U2 - 10.1126/science.1097670

DO - 10.1126/science.1097670

M3 - Article

C2 - 15297676

AN - SCOPUS:3843075120

SN - 0036-8075

VL - 305

SP - 872

EP - 874

JO - Science

JF - Science

IS - 5685

ER -

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this