HIV integration and T cell death: Additional commentary

Arik Cooper; Mayra García; Constantinos Petrovas; Takuya Yamamoto; Richard A. Koup; Gary J. Nabel

doi:10.1186/1742-4690-10-150

HIV integration and T cell death: Additional commentary

Arik Cooper, Mayra García, Constantinos Petrovas, Takuya Yamamoto, Richard A. Koup, Gary J. Nabel

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature 498:376-379, 2013). They have raised several hypothetical points that we further clarify here.

Original language	English (US)
Article number	150
Journal	Retrovirology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/1742-4690-10-150
State	Published - Dec 9 2013
Externally published	Yes

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1186/1742-4690-10-150

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AU - García, Mayra

AU - Petrovas, Constantinos

AU - Yamamoto, Takuya

AU - Koup, Richard A.

AU - Nabel, Gary J.

PY - 2013/12/9

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HIV integration and T cell death: Additional commentary

Abstract

ASJC Scopus subject areas

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