HIV infection and risk behaviors in thai men after their service in the Royal Thai Army: Informing vaccine cohort development

Philip O. Renzullo; David D. Celentano; Chris Beyrer; Sakol Eiumtrakul; John G. McNeil; Robin P. Garner; Cholticha Ruangyuttigarn; Chirasak Khamboonruang; Kenrad E. Nelson

doi:10.1023/A:1025463301921

HIV infection and risk behaviors in thai men after their service in the Royal Thai Army: Informing vaccine cohort development

Philip O. Renzullo, David D. Celentano, Chris Beyrer, Sakol Eiumtrakul, John G. McNeil, Robin P. Garner, Cholticha Ruangyuttigarn, Chirasak Khamboonruang, Kenrad E. Nelson

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A cohort of Royal Thai Army (RTA) conscripts was followed in civilian life after completing 2 years of military service, to determine whether such a cohort might be suitable for HIV vaccine trials. Objectives were to identify correlates of participation and to determine the occurrence of risk behaviors for HIV infection after discharge from the military. The cohort was selected from among conscripts who had participated in HIV studies from 1991 to 1993. Risk factors were surveyed at 3, 9, and 15 months after discharge (1993-1995). Change in risk was evaluated based on deviations from expected distributions of risk categories for sentinel behaviors, assessed with chi- square analysis. HIV seroconversion rates (SR) and 95% confidence intervals (CI) were calculated. A total of 380 men returned after discharge. Seven men seroconverted after discharge; the SR (95% CI) was 2.02/100 person-years (0.814.17). Among changes in risk were reduced visits to commercial sex workers (CSWs), more condom use with CSWs, and less alcohol use prior to CSW visits. Behaviors associated with increased risk of HIV seroconversion declined after military service. Thus, sufficient numbers of outcome events for vaccine trials may not be attained with this type of cohort. Nonetheless, these findings provide data on the dynamics of the HIV epidemic in Thailand and the development of HIV vaccine cohorts.

Original language	English (US)
Pages (from-to)	25-32
Number of pages	8
Journal	AIDS and behavior
Volume	3
Issue number	1
DOIs	https://doi.org/10.1023/A:1025463301921
State	Published - 1999

Keywords

HIV
Military
Risk behaviors
Thailand
Vaccine cohorts

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1023/A:1025463301921

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@article{d50b6f6b6e2d449d97a71184c739d29a,

title = "HIV infection and risk behaviors in thai men after their service in the Royal Thai Army: Informing vaccine cohort development",

abstract = "A cohort of Royal Thai Army (RTA) conscripts was followed in civilian life after completing 2 years of military service, to determine whether such a cohort might be suitable for HIV vaccine trials. Objectives were to identify correlates of participation and to determine the occurrence of risk behaviors for HIV infection after discharge from the military. The cohort was selected from among conscripts who had participated in HIV studies from 1991 to 1993. Risk factors were surveyed at 3, 9, and 15 months after discharge (1993-1995). Change in risk was evaluated based on deviations from expected distributions of risk categories for sentinel behaviors, assessed with chi- square analysis. HIV seroconversion rates (SR) and 95% confidence intervals (CI) were calculated. A total of 380 men returned after discharge. Seven men seroconverted after discharge; the SR (95% CI) was 2.02/100 person-years (0.814.17). Among changes in risk were reduced visits to commercial sex workers (CSWs), more condom use with CSWs, and less alcohol use prior to CSW visits. Behaviors associated with increased risk of HIV seroconversion declined after military service. Thus, sufficient numbers of outcome events for vaccine trials may not be attained with this type of cohort. Nonetheless, these findings provide data on the dynamics of the HIV epidemic in Thailand and the development of HIV vaccine cohorts.",

keywords = "HIV, Military, Risk behaviors, Thailand, Vaccine cohorts",

author = "Renzullo, {Philip O.} and Celentano, {David D.} and Chris Beyrer and Sakol Eiumtrakul and McNeil, {John G.} and Garner, {Robin P.} and Cholticha Ruangyuttigarn and Chirasak Khamboonruang and Nelson, {Kenrad E.}",

note = "Funding Information: The authors thank Surinda Kuntolbutra (JHU) for programming assistance; the staff of the Research Institute for Health Sciences (RIHES), Chiang Mai University, Chiang Mai, Thailand, for data collection and processing; and Peter Lange, RIHES, for administrative support. Follow-up during military service was supported in part by grants from the Rockefeller Foundation, New York, New York. The views ex- pressed herein are the authors' and do not reflect those of the U.S. Department of the Army or U.S. Department of Defense. Funding Information: 1Division of Retrovirology, Walter Reed Army Institute of Research, Washington, D.C. 2Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland. 3Kawila Army Hospital, Royal Thai Army, Chiang Mai, Thailand. 4Henry M. Jackson Foundation, Rockville, Maryland. 5Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand. 6Correspondence should be addressed to John G. McNeil at Division of Retrovirology, Walter Reed Army Institute of Research, 1 Taft Court, Suite 250, Rockville, Maryland 20850 (e-mail: jmcneil@hiv.hjf.org).",

year = "1999",

doi = "10.1023/A:1025463301921",

language = "English (US)",

volume = "3",

pages = "25--32",

journal = "AIDS and behavior",

issn = "1090-7165",

publisher = "Springer New York",

number = "1",

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T1 - HIV infection and risk behaviors in thai men after their service in the Royal Thai Army

T2 - Informing vaccine cohort development

AU - Renzullo, Philip O.

AU - Celentano, David D.

AU - Beyrer, Chris

AU - Eiumtrakul, Sakol

AU - McNeil, John G.

AU - Garner, Robin P.

AU - Ruangyuttigarn, Cholticha

AU - Khamboonruang, Chirasak

AU - Nelson, Kenrad E.

N1 - Funding Information: The authors thank Surinda Kuntolbutra (JHU) for programming assistance; the staff of the Research Institute for Health Sciences (RIHES), Chiang Mai University, Chiang Mai, Thailand, for data collection and processing; and Peter Lange, RIHES, for administrative support. Follow-up during military service was supported in part by grants from the Rockefeller Foundation, New York, New York. The views ex- pressed herein are the authors' and do not reflect those of the U.S. Department of the Army or U.S. Department of Defense. Funding Information: 1Division of Retrovirology, Walter Reed Army Institute of Research, Washington, D.C. 2Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland. 3Kawila Army Hospital, Royal Thai Army, Chiang Mai, Thailand. 4Henry M. Jackson Foundation, Rockville, Maryland. 5Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand. 6Correspondence should be addressed to John G. McNeil at Division of Retrovirology, Walter Reed Army Institute of Research, 1 Taft Court, Suite 250, Rockville, Maryland 20850 (e-mail: jmcneil@hiv.hjf.org).

PY - 1999

Y1 - 1999

N2 - A cohort of Royal Thai Army (RTA) conscripts was followed in civilian life after completing 2 years of military service, to determine whether such a cohort might be suitable for HIV vaccine trials. Objectives were to identify correlates of participation and to determine the occurrence of risk behaviors for HIV infection after discharge from the military. The cohort was selected from among conscripts who had participated in HIV studies from 1991 to 1993. Risk factors were surveyed at 3, 9, and 15 months after discharge (1993-1995). Change in risk was evaluated based on deviations from expected distributions of risk categories for sentinel behaviors, assessed with chi- square analysis. HIV seroconversion rates (SR) and 95% confidence intervals (CI) were calculated. A total of 380 men returned after discharge. Seven men seroconverted after discharge; the SR (95% CI) was 2.02/100 person-years (0.814.17). Among changes in risk were reduced visits to commercial sex workers (CSWs), more condom use with CSWs, and less alcohol use prior to CSW visits. Behaviors associated with increased risk of HIV seroconversion declined after military service. Thus, sufficient numbers of outcome events for vaccine trials may not be attained with this type of cohort. Nonetheless, these findings provide data on the dynamics of the HIV epidemic in Thailand and the development of HIV vaccine cohorts.

AB - A cohort of Royal Thai Army (RTA) conscripts was followed in civilian life after completing 2 years of military service, to determine whether such a cohort might be suitable for HIV vaccine trials. Objectives were to identify correlates of participation and to determine the occurrence of risk behaviors for HIV infection after discharge from the military. The cohort was selected from among conscripts who had participated in HIV studies from 1991 to 1993. Risk factors were surveyed at 3, 9, and 15 months after discharge (1993-1995). Change in risk was evaluated based on deviations from expected distributions of risk categories for sentinel behaviors, assessed with chi- square analysis. HIV seroconversion rates (SR) and 95% confidence intervals (CI) were calculated. A total of 380 men returned after discharge. Seven men seroconverted after discharge; the SR (95% CI) was 2.02/100 person-years (0.814.17). Among changes in risk were reduced visits to commercial sex workers (CSWs), more condom use with CSWs, and less alcohol use prior to CSW visits. Behaviors associated with increased risk of HIV seroconversion declined after military service. Thus, sufficient numbers of outcome events for vaccine trials may not be attained with this type of cohort. Nonetheless, these findings provide data on the dynamics of the HIV epidemic in Thailand and the development of HIV vaccine cohorts.

KW - HIV

KW - Military

KW - Risk behaviors

KW - Thailand

KW - Vaccine cohorts

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HIV infection and risk behaviors in thai men after their service in the Royal Thai Army: Informing vaccine cohort development

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Keywords

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