HIV: hepatic manifestations of HIV and antiretroviral therapy

Yvonne A. Nartey, Kali Zhou, Min Kim, Oluwaseun Falade-Nwulia, Joseph D. Tucker

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hepatic manifestations of HIV infection are common and associated with substantial morbidity and mortality. Infectious etiologies of liver disease (hepatitis A, B, and E infections; hepatic complications of tuberculosis) persist despite the gains made through scaling up antiretroviral therapy. Noncommunicable hepatic complications such as malignancy, steatohepatitis, and drug-related disease are also important considerations. Over one-third of people living with HIV have nonalcoholic fatty liver disease. Antiretroviral therapy may cause severe hepatic complications, including hypersensitivity reactions, direct toxicity, immune reconstitution, and mitochondrial toxicity. Approximately 10% of people living with HIV will have severe hepatotoxicity.

Original languageEnglish (US)
Title of host publicationComprehensive Guide to Hepatitis Advances
PublisherElsevier
Pages525-555
Number of pages31
ISBN (Electronic)9780323983686
ISBN (Print)9780323913102
DOIs
StatePublished - Jan 1 2023

Keywords

  • Antiretroviral therapy
  • HIV
  • Hepatitis B
  • Hepatitis C
  • Hepatitis E
  • Hepatocellular carcinoma
  • Liver cancer
  • Steatohepatitis
  • Tuberculosis

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology

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