Abstract
Hepatic manifestations of HIV infection are common and associated with substantial morbidity and mortality. Infectious etiologies of liver disease (hepatitis A, B, and E infections; hepatic complications of tuberculosis) persist despite the gains made through scaling up antiretroviral therapy. Noncommunicable hepatic complications such as malignancy, steatohepatitis, and drug-related disease are also important considerations. Over one-third of people living with HIV have nonalcoholic fatty liver disease. Antiretroviral therapy may cause severe hepatic complications, including hypersensitivity reactions, direct toxicity, immune reconstitution, and mitochondrial toxicity. Approximately 10% of people living with HIV will have severe hepatotoxicity.
Original language | English (US) |
---|---|
Title of host publication | Comprehensive Guide to Hepatitis Advances |
Publisher | Elsevier |
Pages | 525-555 |
Number of pages | 31 |
ISBN (Electronic) | 9780323983686 |
ISBN (Print) | 9780323913102 |
DOIs | |
State | Published - Jan 1 2023 |
Keywords
- Antiretroviral therapy
- HIV
- Hepatitis B
- Hepatitis C
- Hepatitis E
- Hepatocellular carcinoma
- Liver cancer
- Steatohepatitis
- Tuberculosis
ASJC Scopus subject areas
- General Medicine
- General Immunology and Microbiology