TY - JOUR
T1 - HIV-1 variation before seroconversion in men who have sex with men
T2 - Analysis of acute/early HIV infection in the multicenter AIDS cohort study
AU - Gottlieb, Geoffrey S.
AU - Heath, Laura
AU - Nickle, David C.
AU - Wong, Kim G.
AU - Leach, Stephanie E.
AU - Jacobs, Benjamin
AU - Gezahegne, Surafel
AU - Van 'T Wout, Angélique B.
AU - Jacobson, Lisa P.
AU - Margolick, Joseph B.
AU - Mullins, James I.
N1 - Funding Information:
Financial support: This work was supported by the US Public Health Service (grants R01-AI058894 and R37-AI047734 to G.S.G., J.B.M., and J.I.M. and grant P01-AI57005 to J.I.M.) and the University of Washington Center for AIDS Research and STDs (grant P30-AI27757). The Multicenter AIDS Cohort Study is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute (grants UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, and UO1-AI-35041).
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Understanding the characteristics of human immunodeficiency virus (HIV) necessary for infection in a new host is a critical goal for acquired immunodeficiency syndrome (AIDS) research. We studied the characteristics of HIV-1 envelope genes in 38 men in the Multicenter AIDS Cohort Study cohort before seroconversion. We found a range of diversity (0.2%-5.6% [median, 0.86%]), V1-V2 loop length (58-93 aa), and potential N-linked glycosylation sites (n = 2-9). However, at least 46% of the men had replicating virus that appeared to have been derived from a single viral variant. Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count <200 cells/μL.
AB - Understanding the characteristics of human immunodeficiency virus (HIV) necessary for infection in a new host is a critical goal for acquired immunodeficiency syndrome (AIDS) research. We studied the characteristics of HIV-1 envelope genes in 38 men in the Multicenter AIDS Cohort Study cohort before seroconversion. We found a range of diversity (0.2%-5.6% [median, 0.86%]), V1-V2 loop length (58-93 aa), and potential N-linked glycosylation sites (n = 2-9). However, at least 46% of the men had replicating virus that appeared to have been derived from a single viral variant. Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count <200 cells/μL.
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U2 - 10.1086/529206
DO - 10.1086/529206
M3 - Article
C2 - 18419538
AN - SCOPUS:42549113127
SN - 0022-1899
VL - 197
SP - 1011
EP - 1015
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -