HIV-1 remission and possible cure in a woman after haplo-cord blood transplant

the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1107 Team

doi:10.1016/j.cell.2023.02.030

HIV-1 remission and possible cure in a woman after haplo-cord blood transplant

the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1107 Team

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32) allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant (cord blood cells combined with haploidentical stem cells from an adult) to treat acute myeloid leukemia (AML). Peripheral blood chimerism was 100% CCR5Δ32/Δ32 cord blood by week 14 post-transplant and persisted through 4.8 years of follow-up. Immune reconstitution was associated with (1) loss of detectable replication-competent HIV-1 reservoirs, (2) loss of HIV-1-specific immune responses, (3) in vitro resistance to X4 and R5 laboratory variants, including pre-transplant autologous latent reservoir isolates, and (4) 18 months of HIV-1 control with aviremia, off antiretroviral therapy, starting at 37 months post-transplant. CCR5Δ32/Δ32 haplo-cord transplant achieved remission and a possible HIV-1 cure for a person of diverse ancestry, living with HIV-1, who required a stem cell transplant for acute leukemia.

Original language	English (US)
Pages (from-to)	1115-1126.e8
Journal	Cell
Volume	186
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2023.02.030
State	Published - Mar 16 2023

Keywords

HIV CCR5 dela 32 transplant
HIV cure
HIV remission

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2023.02.030

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title = "HIV-1 remission and possible cure in a woman after haplo-cord blood transplant",

abstract = "Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32) allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant (cord blood cells combined with haploidentical stem cells from an adult) to treat acute myeloid leukemia (AML). Peripheral blood chimerism was 100% CCR5Δ32/Δ32 cord blood by week 14 post-transplant and persisted through 4.8 years of follow-up. Immune reconstitution was associated with (1) loss of detectable replication-competent HIV-1 reservoirs, (2) loss of HIV-1-specific immune responses, (3) in vitro resistance to X4 and R5 laboratory variants, including pre-transplant autologous latent reservoir isolates, and (4) 18 months of HIV-1 control with aviremia, off antiretroviral therapy, starting at 37 months post-transplant. CCR5Δ32/Δ32 haplo-cord transplant achieved remission and a possible HIV-1 cure for a person of diverse ancestry, living with HIV-1, who required a stem cell transplant for acute leukemia.",

keywords = "HIV CCR5 dela 32 transplant, HIV cure, HIV remission",

author = "{the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1107 Team} and Jingmei Hsu and {Van Besien}, Koen and Glesby, {Marshall J.} and Savita Pahwa and Anne Coletti and Warshaw, {Meredith G.} and Larry Petz and Moore, {Theodore B.} and Chen, {Ya Hui} and Suresh Pallikkuth and Adit Dhummakupt and Ruth Cortado and Amanda Golner and Frederic Bone and Maria Baldo and Marcie Riches and Mellors, {John W.} and Tobin, {Nicole H.} and Renee Browning and Deborah Persaud and Yvonne Bryson and Patricia Anthony and Rohan Hazra and Ronald Mitsuyasu and Savita Pahwe and Lawrence Petz and Dwight Yin",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = mar,

day = "16",

doi = "10.1016/j.cell.2023.02.030",

language = "English (US)",

volume = "186",

pages = "1115--1126.e8",

journal = "Cell",

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T1 - HIV-1 remission and possible cure in a woman after haplo-cord blood transplant

AU - the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1107 Team

AU - Hsu, Jingmei

AU - Van Besien, Koen

AU - Glesby, Marshall J.

AU - Pahwa, Savita

AU - Coletti, Anne

AU - Warshaw, Meredith G.

AU - Petz, Larry

AU - Moore, Theodore B.

AU - Chen, Ya Hui

AU - Pallikkuth, Suresh

AU - Dhummakupt, Adit

AU - Cortado, Ruth

AU - Golner, Amanda

AU - Bone, Frederic

AU - Baldo, Maria

AU - Riches, Marcie

AU - Mellors, John W.

AU - Tobin, Nicole H.

AU - Browning, Renee

AU - Persaud, Deborah

AU - Bryson, Yvonne

AU - Anthony, Patricia

AU - Hazra, Rohan

AU - Mitsuyasu, Ronald

AU - Pahwe, Savita

AU - Petz, Lawrence

AU - Yin, Dwight

PY - 2023/3/16

Y1 - 2023/3/16

N2 - Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32) allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant (cord blood cells combined with haploidentical stem cells from an adult) to treat acute myeloid leukemia (AML). Peripheral blood chimerism was 100% CCR5Δ32/Δ32 cord blood by week 14 post-transplant and persisted through 4.8 years of follow-up. Immune reconstitution was associated with (1) loss of detectable replication-competent HIV-1 reservoirs, (2) loss of HIV-1-specific immune responses, (3) in vitro resistance to X4 and R5 laboratory variants, including pre-transplant autologous latent reservoir isolates, and (4) 18 months of HIV-1 control with aviremia, off antiretroviral therapy, starting at 37 months post-transplant. CCR5Δ32/Δ32 haplo-cord transplant achieved remission and a possible HIV-1 cure for a person of diverse ancestry, living with HIV-1, who required a stem cell transplant for acute leukemia.

AB - Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32) allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant (cord blood cells combined with haploidentical stem cells from an adult) to treat acute myeloid leukemia (AML). Peripheral blood chimerism was 100% CCR5Δ32/Δ32 cord blood by week 14 post-transplant and persisted through 4.8 years of follow-up. Immune reconstitution was associated with (1) loss of detectable replication-competent HIV-1 reservoirs, (2) loss of HIV-1-specific immune responses, (3) in vitro resistance to X4 and R5 laboratory variants, including pre-transplant autologous latent reservoir isolates, and (4) 18 months of HIV-1 control with aviremia, off antiretroviral therapy, starting at 37 months post-transplant. CCR5Δ32/Δ32 haplo-cord transplant achieved remission and a possible HIV-1 cure for a person of diverse ancestry, living with HIV-1, who required a stem cell transplant for acute leukemia.

KW - HIV CCR5 dela 32 transplant

KW - HIV cure

KW - HIV remission

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U2 - 10.1016/j.cell.2023.02.030

DO - 10.1016/j.cell.2023.02.030

M3 - Article

C2 - 36931242

AN - SCOPUS:85150339827

SN - 0092-8674

VL - 186

SP - 1115-1126.e8

JO - Cell

JF - Cell

IS - 6

ER -

HIV-1 remission and possible cure in a woman after haplo-cord blood transplant

Abstract

Keywords

ASJC Scopus subject areas

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