Hiv-1 natural antisense transcription and its role in viral persistence

Rui Li, Rachel Sklutuis, Jennifer L. Groebner, Fabio Romerio

Research output: Contribution to journalReview articlepeer-review


Natural antisense transcripts (NATs) represent a class of RNA molecules that are transcribed from the opposite strand of a protein-coding gene, and that have the ability to regulate the expression of their cognate protein-coding gene via multiple mechanisms. NATs have been described in many prokaryotic and eukaryotic systems, as well as in the viruses that infect them. The human immunodeficiency virus (HIV-1) is no exception, and produces one or more NAT from a promoter within the 3’ long terminal repeat. HIV-1 antisense transcripts have been the focus of several studies spanning over 30 years. However, a complete appreciation of the role that these transcripts play in the virus lifecycle is still lacking. In this review, we cover the current knowledge about HIV-1 NATs, discuss some of the questions that are still open and identify possible areas of future research.

Original languageEnglish (US)
Article number795
Issue number5
StatePublished - May 2021


  • Epigenetic silencing
  • Expression
  • HIV-1
  • Latency
  • Long non-coding RNA
  • Natural antisense transcription
  • Persis-tence

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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