TY - JOUR
T1 - HIV-1-induced depletion of CD4+ T cells in the gut
T2 - Mechanism and therapeutic implications
AU - Chase, Amanda
AU - Zhou, Yan
AU - Siliciano, Robert F.
N1 - Funding Information:
This work was supported by NIH grants AI43222 and AI51178, a grant from the Doris Duke Charitable Foundation, and the Howard Hughes Medical Institute.
PY - 2006/1
Y1 - 2006/1
N2 - The mechanism of CD4+ T-cell depletion remains a central unresolved issue in AIDS research. Recent studies have examined the massive depletion of CD4+ T cells observed in macaque models of acute HIV infection. A key question is whether the observed CD4+ T-cell death is due to direct consequences of viral infection and to indirect mechanisms including increased expression of mediators of T-cell apoptosis. The therapeutic implications of the early CD4+ T-cell loss are discussed.
AB - The mechanism of CD4+ T-cell depletion remains a central unresolved issue in AIDS research. Recent studies have examined the massive depletion of CD4+ T cells observed in macaque models of acute HIV infection. A key question is whether the observed CD4+ T-cell death is due to direct consequences of viral infection and to indirect mechanisms including increased expression of mediators of T-cell apoptosis. The therapeutic implications of the early CD4+ T-cell loss are discussed.
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U2 - 10.1016/j.tips.2005.11.005
DO - 10.1016/j.tips.2005.11.005
M3 - Short survey
C2 - 16337692
AN - SCOPUS:30344485969
SN - 0165-6147
VL - 27
SP - 4
EP - 7
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 1
ER -