HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients with low-level viremia

Christine M. Durand; Karen A. O'Connell; Linda G. Apuzzo; Susan J. Langan; Hejab Imteyaz; Aima A. Ahonkhai; Christina M. Ceccato; Thomas M. Williams; Joseph B. Margolick; Joel N. Blankson

doi:10.1097/QAD.0b013e32833d8a38

HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients with low-level viremia

Christine M. Durand, Karen A. O'Connell, Linda G. Apuzzo, Susan J. Langan, Hejab Imteyaz, Aima A. Ahonkhai, Christina M. Ceccato, Thomas M. Williams, Joseph B. Margolick, Joel N. Blankson

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We studied viral evolution in five human leukocyte antigen (HLA)-B*57 patients recently infected with HIV-1. Escape mutations in HLA-B*57- restricted Gag epitopes were present at study entry in all patients, but were not associated with significant increases in viremia. Conversely, no new escape mutations in HLA-B*57-restricted epitopes or known compensatory mutations were detected in patients who experienced significant increases in viremia. Thus, the development of escape mutations alone does not determine virologic outcome in recently infected HLA-B*57 patients.

Original language	English (US)
Pages (from-to)	2405-2408
Number of pages	4
Journal	AIDS
Volume	24
Issue number	15
DOIs	https://doi.org/10.1097/QAD.0b013e32833d8a38
State	Published - Sep 24 2010

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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title = "HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients with low-level viremia",

abstract = "We studied viral evolution in five human leukocyte antigen (HLA)-B*57 patients recently infected with HIV-1. Escape mutations in HLA-B*57- restricted Gag epitopes were present at study entry in all patients, but were not associated with significant increases in viremia. Conversely, no new escape mutations in HLA-B*57-restricted epitopes or known compensatory mutations were detected in patients who experienced significant increases in viremia. Thus, the development of escape mutations alone does not determine virologic outcome in recently infected HLA-B*57 patients.",

author = "Durand, {Christine M.} and O'Connell, {Karen A.} and Apuzzo, {Linda G.} and Langan, {Susan J.} and Hejab Imteyaz and Ahonkhai, {Aima A.} and Ceccato, {Christina M.} and Williams, {Thomas M.} and Margolick, {Joseph B.} and Blankson, {Joel N.}",

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AU - Durand, Christine M.

AU - O'Connell, Karen A.

AU - Apuzzo, Linda G.

AU - Langan, Susan J.

AU - Imteyaz, Hejab

AU - Ahonkhai, Aima A.

AU - Ceccato, Christina M.

AU - Williams, Thomas M.

AU - Margolick, Joseph B.

AU - Blankson, Joel N.

PY - 2010/9/24

Y1 - 2010/9/24

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AB - We studied viral evolution in five human leukocyte antigen (HLA)-B*57 patients recently infected with HIV-1. Escape mutations in HLA-B*57- restricted Gag epitopes were present at study entry in all patients, but were not associated with significant increases in viremia. Conversely, no new escape mutations in HLA-B*57-restricted epitopes or known compensatory mutations were detected in patients who experienced significant increases in viremia. Thus, the development of escape mutations alone does not determine virologic outcome in recently infected HLA-B*57 patients.

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HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients with low-level viremia

Abstract

ASJC Scopus subject areas

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