HIV-1 Gag and Vpr impair the inflammasome activation and contribute to the establishment of chronic infection in human primary macrophages

Keyphrases

• Human Immunodeficiency Virus Type 1 (HIV-1) 100%
• Infected Macrophages 100%
• Primary Macrophages 100%
• Chronic Infection 100%
• HIV-1 Infection 100%
• HIV-1 Gag 100%
• Inflammasome Activation 100%
• HIV-1 PR 100%
• Immune Response 66%
• Viral Glycoprotein 66%
• Infected Cells 66%
• NOD-like Receptor Protein 3 (NLRP3) 66%
• Cellular Proteins 33%
• Inflammatory Cytokines 33%
• Viral Replication 33%
• Age of Infection 33%
• Interleukin-1β 33%
• NF-B 33%
• Retinoic Acid-inducible Gene I (RIG-I) 33%
• CXCL10 33%
• ROS Production 33%
• Cellular Mechanisms 33%
• Structural Alterations 33%
• Macrophages 33%
• Caspase-1 33%
• Culture Supernatant 33%
• Supernatant 33%
• Host Cell Proteins 33%
• Immunofluorescence Analysis 33%
• Inflammasome 33%
• In Silico Prediction 33%
• Viral Evasion 33%
• Viral Mechanisms 33%
• Mitochondrial Architecture 33%
• Alternative Patterns 33%
• Classical Patterns 33%
• Inflammasome Pathway 33%
• ASC Speck 33%
• Prediction Studies 33%
• LTB4 33%

Immunology and Microbiology

• Human Immunodeficiency Virus 1 100%
• Macrophage 100%
• Vpr 100%
• Inflammasome 100%
• Infection 100%
• Infectious Disease 66%
• Immune Response 22%
• NLRP3 22%
• Viral Replication 11%
• Interleukin 1 11%
• CXCL10 11%
• Proinflammatory Cytokine 11%
• Immunofluorescence 11%
• Supernatant 11%
• AIM2 11%
• RIG-I 11%