History of the development of oral rehydration fluids

R. Bradley Sack

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The development of oral rehydration fluid for the treatment of cholera and other diarrhoeal diseases has been regarded as one of the most important medical advances of the last century. This article summarises information on how this achievement was made possible. The development is traced from the historical empiric use of oral fluids for treating diarrhoea, to physiologic studies in animals that defined how glucose and sodium were coupled in absorption by the small intestine and finally, to the use of this knowledge in developing the simple effective solutions that were adopted by WHO as the mainstay of diarrhoeal therapy worldwide.

Original languageEnglish (US)
Pages (from-to)360-364
Number of pages5
JournalJournal of the Indian Medical Association
Issue number6
StatePublished - Jun 1 2003
Externally publishedYes


  • History of the development
  • Oral rehydration on fluid (solution)
  • Watery diarrhoeal diseases

ASJC Scopus subject areas

  • Medicine(all)


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