Histopathologic characterization of hereditary benign prostatic hyperplasia

Christopher B. Doehring, Martin G. Sanda, Alan Partin, Jurga Sauvageot, Hank Juo, Terri H. Beaty, Jonathan Epstein, Gary Hill, Patrick C. Walsh

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objectives. Recent studies suggest the presence of a hereditary form of benign prostatic hyperplasia (H-BPH). This study was undertaken to characterize the histopathologic features of BPH in these men. Methods. Because study subjects with H-BPH were young (mean age 59 years) and had a large prostate (mean prostate weight 61 g), we compared the histopathologic findings in these men with those in two different control groups: (1) age- matched control subjects (mean age 59 years; mean prostate weight 31 g), and (2) prostate weight-matched control subjects (mean age 70 years; mean prostate weight 61 g). Using a color video image analysis system, we morphometrically determined stromal/epithelial ratios in histologic sections taken from 12 men with H-BPH, 36 age-matched control subjects, and 36 prostate weight-matched control subjects. Results. The stromal/epithelial ratio was 2.6 ± 1.4 in the men with H-BPH, 2.7 ± 1.7 in the age-matched control subjects, and 1.7 ± 0.9 in the prostate weight-matched control subjects. Regression analysis, which controlled for the differences in prostate weight or patient age between men with H-BPH and age-matched and prostate weight-matched control subjects, respectively, revealed a significant difference between men with H-BPH and prostate weight-matched control subjects (P = 0.015) but no difference from age-matched control subjects (P = 0.36). Conclusions. The larger prostates in young men with H- BPH are characterized by a higher stromal/epithelial ratio than are similar- sized prostates in older men with sporadic BPH. This finding gives rise to speculation that H-BPH is associated with an increase in stromal elements.

Original languageEnglish (US)
Pages (from-to)650-653
Number of pages4
Issue number4
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Urology


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