Histology and angiography in a bifurcation aneurysm model

Matthew R. Quigley, Gerald F. Tuite, Jeffrey W. Cozzens

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Laser-sealed arteriotomy has recently been shown to produce a reliable saccular aneurysm model. By applying this method to the rat abdominal aorta and performing serial angiography, the behavior of this aneurysm model at an arterial bifurcation has been studied for the first time. Three days after laser-sealed arteriotomy, no aneurysms were found, but in animals studied 7, 14, 21, and 28 days after laser-sealed arteriotomy, a 100% (17/17) aneurysm formation rate was achieved. Serial angiography did not demonstrate significant changes in size when performed at 2-week intervals, but angiography significantly underestimated true aneurysm size (p < 0.001) as a function of increasing aneurysm diameter (p < 0.001). By light-microscopic analysis, these aneurysms were similar to human cerebral saccular aneurysms. This saccular aneurysm model could be used to study various surgical and interventional radiology techniques in experimental animals.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalSurgical neurology
Issue number6
StatePublished - Dec 1988
Externally publishedYes


  • Aneurysm
  • Angiography
  • Histology
  • Laser
  • Model
  • Rat

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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