Histological features of osteofibrous hemangioma of the maxillofacial and skull base regions

Sofia Stamataki, Howard W. Francis, Michael Holliday, Edward McCarthy

Research output: Contribution to journalArticlepeer-review


Objectives: The histological spectrum of hemangiomas of the skull base and maxillofacial skeleton was evaluated to help explain the variability of the clinical and radiological presentation of this tumor. Design: Retrospective case series. Participants: Patients with surgically treated hemangiomas of the ear, sinuses, skull base, and maxillofacial bones. Method: Light microscopic appearance of surgical specimens. Results: Review of specimens from 23 tumors revealed two distinct histological patterns: 1) typical histology consisting of vascular spaces lined by endothelium and a thin layer of smooth muscle, and 2) osteofibrous histology that consisted of prominent fibrous tissue between vascular spaces associated occasionally with neo-osseogenesis. The osteofibrous histology was more prevalent in the sinonasal and anterior skull base regions compared to the internal auditory canal. Conclusions: Connective tissue and bony proliferation within hemangiomas vary according to tumor location and may have implications for the radiological appearance, ease of surgical resection, and associated morbidity.

Original languageEnglish (US)
Pages (from-to)587-593
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Issue number5
StatePublished - May 2008

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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