Histological Characteristics of Breast Carcinoma in Blacks and Whites

Vivien W. Chen, Pelayo Correa, Xiao Cheng Wu, Mahboob Sobhan, Robert J. Kurman, J. William Eley, Ralph Coates, Donald Austin, Peggy Reynolds, Hyman Muss, Carrie P. Hunter, Carol Redmond, Allen A. Herman, Brenda K. Edwards

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162 Scopus citations


Tumor characteristics of 963 newly diagnosed invasive breast cancer cases from the population-based Black/ White Cancer Survival Study were evaluated. Representative slides of the tumors were requested from all participating hospitals of three metropolitan areas and reviewed by one expert pathologist, blinded in regard to the age and race of patients. Nine tumor characteristics were evaluated for black and white patients. After adjusting for age, stage, and metropolitan area, blacks were significantly more likely to have high grade nuclear atypia [odds ratio (OR) = 1.97, 95% confidence interval (CI) = 1.27-3.04]; high mitotic activity (OR = 2.05, 95% CI = 1.34-3.14), grade 3 tumors (OR = 1.58, 95% CI = 1.02-2.45), and more necrosis (OR = 1.51, 95% CI = 1.16-1.98); and less likely to have well defined tubulär formation (OR = 0.57, 95% CI = 0.42-0.77), marked fibrosis (OR = 0.65, 95% CI = 0.45-0.94), and positive estrogen receptor Status (OR = 0.78, 95% CI = 0.58-1.05). These black/white differences remained after controlling for socioeconomic Status (SES), body mass index, use of alcohol and tobacco, reproductive experience, and health care access and utilization. No significant racial differences were found for blood vessel invasion and lymphatic invasion. Although white women of high SES.

Original languageEnglish (US)
Pages (from-to)127-135
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Issue number2
StatePublished - Mar 1 1994

ASJC Scopus subject areas

  • General Medicine


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