Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas

Yao S. Fu, Lundy Braun, Keerti V. Shah, W. Dwayne Lawrence, Stanley J. Robboy

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Fifty‐four cervical condylomatous lesions, with and without nuclear atypia, from 42 women, were studied with the Feulgen microspectrophotometric technique for nuclear DNA quantitation and an immunoperoxidase technique for human papillomavirus (HPV) antigen. All ordinary cervical condylomas (without atypia/dysplasia) had a diploid or polyploid nuclear DNA distribution; 61% had detectable HPV antigen. Among the cervical condylomas with atypia/dysplasia, 55% (17/31) had diploid or polyploid nuclear DNA pattern, and, of these, 59% (10/17) had demonstrable papillomavirus antigen. Fourteen (45%) were aneuploid lesions, 2 of which had a small number of cells with papillomavirus antigen (14%). These findings suggest that the majority of cervical condylomas are related to papillomavirus infection. That lesions with dysplasia, including high degrees of dysplasia, may also exhibit coexistence of papillomavirus infection suggests the possibility of an infectious etiology in the genesis of cervical squamous neoplasia.

Original languageEnglish (US)
Pages (from-to)1705-1711
Number of pages7
Issue number9
StatePublished - Nov 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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