TY - JOUR
T1 - Histologic effects of fractional laser and radiofrequency devices on hyaluronic acid filler
AU - Hsu, Sarah Hahn
AU - Chung, Hye Jin
AU - Weiss, Robert A.
N1 - Publisher Copyright:
© 2018 by the American Society for Dermatologic Surgery, Inc.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - BACKGROUNDHyaluronic acid fillers (HAFs) and energy-based devices are frequently used sequentially. However, the effect of using fractional devices directly over HAF is unclear.OBJECTIVETo evaluate histologic changes after fractional laser and radiofrequency (RF) therapies applied over preinjected HAF.MATERIALS AND METHODSAbdominoplasty skin samples were divided into 8 zones. Intradermal injections of HAF were performed to 7 zones with 1 zone as untreated control. Six of 7 HAF injected zones were then treated with the following devices: 1,540-, 1,550-, 1927-, and 10,600-nm fractional lasers, and fractional bipolar RF delivered through insulated and noninsulated microneedles. After treatment, biopsies were collected for H&E staining.RESULTSHistology revealed HAF in the mid to deep dermis. Treatment with 1,540-, 1,550-, 1927-, and 10,600-nm lasers did not result in any morphologic changes of HAF, although thermal changes from 1,540-and 1,550-nm lasers were in very close proximity to the filler. The RF devices demonstrated thermal damage of HAF along the microneedle tracks.CONCLUSIONHyaluronic acid filler is unaffected by fractional lasers in this model. Fractional RF devices, which produce deeper dermal penetrations, will cause thermal damage of HAF. Caution is advised in using microneedle RF over recently injected filler. Study limitations include use of nonfacial skin and lack of inflammatory response in an ex-vivo model.
AB - BACKGROUNDHyaluronic acid fillers (HAFs) and energy-based devices are frequently used sequentially. However, the effect of using fractional devices directly over HAF is unclear.OBJECTIVETo evaluate histologic changes after fractional laser and radiofrequency (RF) therapies applied over preinjected HAF.MATERIALS AND METHODSAbdominoplasty skin samples were divided into 8 zones. Intradermal injections of HAF were performed to 7 zones with 1 zone as untreated control. Six of 7 HAF injected zones were then treated with the following devices: 1,540-, 1,550-, 1927-, and 10,600-nm fractional lasers, and fractional bipolar RF delivered through insulated and noninsulated microneedles. After treatment, biopsies were collected for H&E staining.RESULTSHistology revealed HAF in the mid to deep dermis. Treatment with 1,540-, 1,550-, 1927-, and 10,600-nm lasers did not result in any morphologic changes of HAF, although thermal changes from 1,540-and 1,550-nm lasers were in very close proximity to the filler. The RF devices demonstrated thermal damage of HAF along the microneedle tracks.CONCLUSIONHyaluronic acid filler is unaffected by fractional lasers in this model. Fractional RF devices, which produce deeper dermal penetrations, will cause thermal damage of HAF. Caution is advised in using microneedle RF over recently injected filler. Study limitations include use of nonfacial skin and lack of inflammatory response in an ex-vivo model.
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U2 - 10.1097/DSS.0000000000001716
DO - 10.1097/DSS.0000000000001716
M3 - Article
C2 - 30570514
AN - SCOPUS:85064239844
SN - 1076-0512
VL - 45
SP - 552
EP - 556
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 4
ER -