Histamine in nasal secretions

P. A. Eggleston, J. O. Hendley, J. M. Gwaltney, A. W. Eggleston, B. S. Leavell

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The histamine content of secretions collected by small-volume nasal washes was assayed by a spectrophotofluorometric method. A wide range of histamine concentrations (< 5 - 1,519 ng/ml) was found. The mean concentration in secretions from normal individuals (91 ng/ml) was not significantly different from that found in allergic individuals (51 ng/ml). Females had significantly lower concentrations than did males. Sequential sampling in normals and allergics showed a great deal of daily variation in histamine content. This technically simple method may prove useful in examining the epidemiology and pathophysiology of allergic rhinitis.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalUnknown Journal
Issue number3
StatePublished - 1978

ASJC Scopus subject areas

  • Immunology and Allergy


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