Histamine H1-receptors labeled in vivo: Antidepressant and antihistamine interactions

David Diffley, Vinh Tan Tran, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


3H-Mepyramine labels specific histamine H1-receptors in brains of mice after intravenous injection. The potencies of H1-antihistamines in reducing 3H-mepyramine binding in vivo correspond to their pharmacological activities and show parallels with their affinities for 3H-mepyramine binding sites in isolated brain membranes. Several antidepressants are potent in competing for 3H-mepyramine binding in vivo as well as in vitro.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number2-3
StatePublished - Jun 13 1980


  • H-Mepyramine
  • Histamine H-receptors
  • Labeling in vivo
  • Sedation
  • Tricyclic antidepressants

ASJC Scopus subject areas

  • Pharmacology


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