Histamine H1-receptors labeled in vivo: Antidepressant and antihistamine interactions

David Diffley; Vinh Tan Tran; Solomon H. Snyder

doi:10.1016/0014-2999(80)90043-6

Histamine H₁-receptors labeled in vivo: Antidepressant and antihistamine interactions

David Diffley, Vinh Tan Tran, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

³H-Mepyramine labels specific histamine H₁-receptors in brains of mice after intravenous injection. The potencies of H₁-antihistamines in reducing ³H-mepyramine binding in vivo correspond to their pharmacological activities and show parallels with their affinities for ³H-mepyramine binding sites in isolated brain membranes. Several antidepressants are potent in competing for ³H-mepyramine binding in vivo as well as in vitro.

Original language	English (US)
Pages (from-to)	177-181
Number of pages	5
Journal	European Journal of Pharmacology
Volume	64
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(80)90043-6
State	Published - Jun 13 1980

Keywords

H-Mepyramine
Histamine H-receptors
Labeling in vivo
Sedation
Tricyclic antidepressants

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(80)90043-6

Cite this

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title = "Histamine H1-receptors labeled in vivo: Antidepressant and antihistamine interactions",

abstract = "3H-Mepyramine labels specific histamine H1-receptors in brains of mice after intravenous injection. The potencies of H1-antihistamines in reducing 3H-mepyramine binding in vivo correspond to their pharmacological activities and show parallels with their affinities for 3H-mepyramine binding sites in isolated brain membranes. Several antidepressants are potent in competing for 3H-mepyramine binding in vivo as well as in vitro.",

keywords = "H-Mepyramine, Histamine H-receptors, Labeling in vivo, Sedation, Tricyclic antidepressants",

author = "David Diffley and Tran, {Vinh Tan} and Snyder, {Solomon H.}",

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AU - Diffley, David

AU - Tran, Vinh Tan

AU - Snyder, Solomon H.

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Y1 - 1980/6/13

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AB - 3H-Mepyramine labels specific histamine H1-receptors in brains of mice after intravenous injection. The potencies of H1-antihistamines in reducing 3H-mepyramine binding in vivo correspond to their pharmacological activities and show parallels with their affinities for 3H-mepyramine binding sites in isolated brain membranes. Several antidepressants are potent in competing for 3H-mepyramine binding in vivo as well as in vitro.

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KW - Labeling in vivo

KW - Sedation

KW - Tricyclic antidepressants

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